depmap

Sample analysis of Cancer Dependency Map (DepMap) data

Request

Identify the most frequent genetic alterations (could be mutations or copy number variations) in the cancer cell lines
Match them with the best genetic dependencies that could be used for drug development for the cancers that carry those mutations
Take into account the lineage of cancer cell lines (certain mutations/CNVs may be restricted to a specific lineage)

Resources

DepMap (https://depmap.org/portal) Data

Cell line metadata
Expression (RNASeq)
Copy number variation
Mutations
Genetic dependency
- Crispr (Achilles)
- RNAi (DEMETER2)

Citations:

Jordan G. Bryan, John M. Krill-Burger, Thomas M. Green, Francisca Vazquez, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Aviad Tsherniak. (2018). Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nature Communications 9, 1. https://doi.org/10.1038/s41467-018-06916-5</font>
DepMap, Broad (2019): DepMap 19Q3 Public. figshare. Dataset doi:10.6084/m9.figshare.9201770.v1.
Robin M. Meyers, Jordan G. Bryan, James M. McFarland, Barbara A. Weir, … David E. Root, William C. Hahn, Aviad Tsherniak. Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics 2017 October 49:1779–1784. doi:10.1038/ng.3984

Jupyter (https://jupyter.org/)

Python programming framework for analysis prototyping and reporting

GitHub (https://github.com/)

Revision control for Python code
Reporting mechanism for analysis summary and details

Analysis overview

Aggregate data from depmap.org
Deal with various data format issues
Map cell lines to cancer lineages and sublineages
Capture low-hanging fruit genes with high copy number and gene dependency (Achilles Crispr) scores < 0
Sanity check filters using ERBB2 as a known truth
Compare RNAi and Crispr gene dependency data
Plot copy number vs. gene dependency by lineage
Generate list of candidate genes as a sortable table
Add cross-validation/filtering data for RNAi, expression, TGCA/COSMIC mutation hotspots
target gene info pages

Next steps

Improve thresholds (cutoffs for copy number, gene dependency, expression TPMs, etc.)
Integrate chemical sensitivity data
Use pathways, networks etc (eg: https://www.nature.com/articles/s41598-019-40780-7) to group targets
Filter genes that are already known drug targets (identify truly novel targets)

Analysis details

Python code Details…

Aggregate CCLE cell lines by lineage

DepMap source file: sample_info.csv

Group all cell lines (CCLE cell line IDs) by main (parent) lineage
If a lineage has > 1 defined sublineages, also aggregate cell lines by sublineage (eg: leukemia -> AML)

Number of cell lines: 1429
Number of lineages: 33
Number of lineages with sub-lineages: 16
Number of sub-lineages 61

Expression Data (RNASeq)

RNAseq TPM gene expression data for just protein coding genes using RSEM. Log2 transformed, using a pseudo-count of 1.

DepMap source file: CCLE_expression.csv

Transpose columns (gene names) and rows (CCLE cell line IDs)
Translate gene names to NCBI gene IDs

Mutation Data

DepMap source file: CCLE_mutations.csv

Keep track of TCGA and COSMIC hotspot genes by lineage
Just using hotspot genes for now but track deleterious mutations by lineage for future reference

8704 TCGA or COSMIC hotspot genes

Copy number data

Gene level copy number data, log2 transformed with a pseudo count of 1. This is generated by mapping genes onto the segment level calls.

Depmap source file: CCLE_gene_cn_v2.csv

Transpose columns (gene names) and rows (CCLE cell line IDs)
Translate gene names to NCBI gene IDs

Search for high copy number genes in each of the lineages

Filtering only genes with copy number > 2 in all cell lines in a lineage is a bit too stringent
Retain genes that have copy number >= 2 in 80% or more cell lines in a lineage
Extract the data for any cell lines with high copy number genes to use as plotting baseline

lung_immortalized; 1 cell lines; 6 high copy number genes
lymphoblastic_lymphoma; 1 cell lines; 311 high copy number genes
adrenal_cortex; 1 cell lines; 200 high copy number genes
esophagus_adenocarcinoma; 7 cell lines; 7 high copy number genes
bone_chordoma; 4 cell lines; 11 high copy number genes
breast_ERneg; 1 cell lines; 960 high copy number genes
breast_immortalized; 2 cell lines; 8 high copy number genes
breast_HER2Amp; 13 cell lines; 11 high copy number genes
peripheral_nervous_system_PNET; 1 cell lines; 22 high copy number genes
ovary_immortalized; 1 cell lines; 9 high copy number genes
eye_uveal_melanoma; 5 cell lines; 1016 high copy number genes
central_nervous_system_immortalized; 1 cell lines; 26 high copy number genes
central_nervous_system_PNET; 1 cell lines; 2 high copy number genes
soft_tissue_epitheliod_sarcoma; 2 cell lines; 2 high copy number genes
soft_tissue_liposarcoma; 5 cell lines; 44 high copy number genes
soft_tissue_sarcoma_undifferentiated; 2 cell lines; 164 high copy number genes
soft_tissue_fibrosarcoma; 1 cell lines; 2 high copy number genes
gastric_adenosquamous; 1 cell lines; 508 high copy number genes
skin_epidermoid_carcinoma; 1 cell lines; 234 high copy number genes
skin_squamous; 3 cell lines; 251 high copy number genes
upper_aerodigestive_buccal_mucosa; 1 cell lines; 592 high copy number genes

DEMETER2 RNAi gene dependency data

Cancer cell line genetic dependencies estimated using the DEMETER2 model. DEMETER2 is applied to three large-scale RNAi screening datasets: the Broad Institute Project Achilles, Novartis Project DRIVE, and the Marcotte et al. breast cell line dataset. The model is also applied to generate a combined dataset of gene dependencies covering a total of 712 unique cancer cell lines.

DepMap source file: D2_combined_gene_dep_scores.csv

Data source uses CCLE names rather than DepMap cell line IDS
Translate the cell line names to IDS for consistency with other data sources
Also deal with rows in the table with multiple gene names (eg ‘GTF2IP4&GTF2IP1 (100093631&2970)’)

Achilles Crispr gene dependency data

CERES data with principle components strongly related to known batch effects removed, then shifted and scaled per cell line so the median nonessential KO effect is 0 and the median essential KO effect is -1.

DepMap source file: Achilles_gene_effect.csv

Translate gene names (column labels) to NCBI IDS
Transpose rows and columns so each cell line is a column label with vertivally stacked gene data

How many cell lines and genes are shared between D2 (RNAi) and Achilles (Crispr) gene dependency data sets?

423 cell lines are shared
16052 genes are shared

How well do VCrispr and RNAi compare

significant p-value means reject H0 that slope == 0
For now, accept Achilles (Crispr) as canonical for gene dependency score but keep RNAi data fro cross-validation/concordance

Sanity checking with ERBB2 (2064)

Do my filters capture a known target?

Evaluating breast cancer lineages where at least one cell line had copy number > 2:
Is ERB2B in the hotspot gene set?
We expect ERBB2 to have high copy number in breast cancer lineages ** What is the mean ERB2B copy number in breast cancers?
The gene dependency score should be < 0 ** What is the mean gene dependency score in breast cancers?

ERBB2 is in hotspot gene set? TRUE

ERBB2 mean copy number for breast_TNBC (27 cell lines): 1.89
ERBB2 mean copy number for breast_TPBC (5 cell lines): 9.59
ERBB2 mean copy number for breast_HER2Amp (11 cell lines): 14.84
ERBB2 mean gene dependency for breast_HER2Amp (6 cell lines): -0.83
ERBB2 mean gene dependency for breast_ERpos (7 cell lines): -0.27
ERBB2 mean gene dependency for breast_TNBC (15 cell lines): -0.28

Lineages with observed high copy number genes

Go through the list of lineages with high copy number genes
Plot gene dependency vs. copy number
Highlight genes/cell-lines with copy number > 2 and gene dependency < 0 for specific lineages

Copy number vs gene dependency

Candidate target genes

All genes in this table have copy number > 2 and Achilles gene dependency < 0 for at least 80% of the cell lines in 1 cell lineage
Other data for cross-validation:
- RNAi gene dependency score
- Whether the gene is a TCGA or COSMIC mutation hotspot
- Whether the gene has > 0 TPM RNASeq expression
Click the gene symbol for information about target gene

Candidate genes

DepMap_ID	sublineage	HUGO_symbol	Entrez_ID	copy_number	achilles_gene_dep	rnai_gene_dep	hotspot	rnaseq_expressed
ACH-001523	skin_squamous	OTULIN	90268	3.020449	-0.285715	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RAB6A	5870	2.616111	-0.916588	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ARAP1	116985	2.616111	-0.017861	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GUCD1	83606	3.253533	-0.338554	NaN	False	True
ACH-001554	eye_uveal_melanoma	KCNV1	27012	2.701722	-0.007792	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	HERC1	8925	3.946118	-0.090020	NaN	True	True
ACH-001521	skin_squamous	ROPN1L	83853	2.355673	-0.195630	NaN	False	True
ACH-001554	eye_uveal_melanoma	VXN	254778	2.267856	-0.035411	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TRIM49C	642612	2.991123	-0.456054	NaN	False	False
ACH-001328	skin_epidermoid_carcinoma	ABCC10	89845	2.060374	-0.260400	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	CCT6A	908	4.556424	-0.655467	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TESMIN	9633	2.454952	-0.362325	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	GSTA5	221357	2.060374	-0.072587	NaN	False	False
ACH-001554	eye_uveal_melanoma	C8orf44	56260	2.267856	-0.034882	NaN	False	True
ACH-000280	ovary_non_epithelial	OR4N2	390429	2.776707	-0.605942	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	SLC27A2	11001	2.028902	-0.354914	NaN	True	True
ACH-001554	eye_uveal_melanoma	LRRC14	9684	2.701722	-0.083453	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CHKA	1119	2.454952	-0.464088	NaN	True	True
ACH-000025	central_nervous_system_meningioma	ITPKB	3707	2.153077	-0.142118	-0.170103	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DDI1	414301	2.482392	-0.015989	NaN	True	False
ACH-001554	eye_uveal_melanoma	ZBTB10	65986	2.267856	-0.009756	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ANO1	55107	2.454952	-0.348054	NaN	True	True
ACH-000280	ovary_non_epithelial	KANK4	163782	3.466104	-0.289718	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	CLIC5	53405	2.060374	-0.177123	NaN	False	True
ACH-001956	bone_chordoma	DENND1C	79958	2.256600	-0.019082	NaN	True	False
ACH-001554	eye_uveal_melanoma	C8orf33	65265	2.701722	-0.674926	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CARD16	114769	2.482392	-0.330623	NaN	True	True
ACH-001554	eye_uveal_melanoma	AP3M2	10947	2.267856	-0.140228	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PITRM1	10531	4.005696	-0.464557	NaN	False	True
ACH-001554	eye_uveal_melanoma	RAD21	5885	2.701722	-1.104199	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PPFIA1	8500	2.775982	-0.192437	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MMP11	4320	2.543976	-0.203251	NaN	False	True
ACH-001524	skin_squamous	SLC9A3	6550	2.061718	-0.346297	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MRPL48	51642	2.616111	-0.394075	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FAM86C1	55199	2.775982	-0.384972	NaN	False	True
ACH-001554	eye_uveal_melanoma	PTDSS1	9791	2.701722	-0.315504	NaN	True	True
ACH-000859	breast_HER2Amp	ERBB2	2064	54.124990	-0.078245	-0.401528	True	True
ACH-001521	skin_squamous	LRRC14B	389257	2.869776	-0.179089	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	PLA2G4E	123745	2.039894	-0.211879	NaN	False	True
ACH-001524	skin_squamous	CPLANE1	65250	2.007874	-0.299102	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TTC28	23331	2.612317	-0.166260	NaN	False	True
ACH-001554	eye_uveal_melanoma	MED30	90390	2.701722	-1.611398	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PLEKHS1	79949	4.108162	-0.250361	NaN	True	False
ACH-001523	skin_squamous	FBXL7	23194	3.020449	-0.029360	NaN	True	True
ACH-001554	eye_uveal_melanoma	GPIHBP1	338328	2.701722	-0.243351	NaN	False	False
ACH-001524	skin_squamous	ZDHHC11B	653082	2.061718	-0.057322	NaN	False	True
ACH-001523	skin_squamous	TRIP13	9319	3.020449	-0.742466	NaN	False	True
ACH-001524	skin_squamous	EXOC3	11336	2.061718	-0.598535	NaN	False	True
ACH-001523	skin_squamous	TENT4A	11044	3.020449	-0.397617	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KRTAP5-7	440050	2.775982	-0.982457	NaN	False	True
ACH-001554	eye_uveal_melanoma	CCAR2	57805	2.267856	-0.134606	NaN	True	True
ACH-001554	eye_uveal_melanoma	ENPP2	5168	2.701722	-0.093749	NaN	True	True
ACH-001554	eye_uveal_melanoma	SDCBP	6386	2.267856	-0.105716	NaN	False	True
ACH-000725	breast_HER2Amp	ERBB2	2064	9.359315	-1.224299	-0.757990	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TPCN2	219931	2.454952	-0.025322	NaN	True	True
ACH-001554	eye_uveal_melanoma	VPS28	51160	2.701722	-0.893618	NaN	True	True
ACH-001523	skin_squamous	ANKRD33B	651746	3.020449	-0.196328	NaN	False	True
ACH-001524	skin_squamous	MRPL36	64979	2.007874	-0.451559	NaN	False	True
ACH-001523	skin_squamous	DNAH5	1767	3.020449	-0.300428	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PRSS23	11098	2.677035	-0.011048	NaN	True	True
ACH-001523	skin_squamous	RAD1	5810	3.020449	-0.185788	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	GSTA3	2940	2.060374	-0.095641	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	USP50	373509	2.028902	-0.484171	NaN	False	True
ACH-001524	skin_squamous	SKP2	6502	2.007874	-0.525092	NaN	False	True
ACH-001524	skin_squamous	TRIP13	9319	2.007874	-0.462186	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KCTD21	283219	2.677035	-0.289684	NaN	True	True
ACH-001523	skin_squamous	SDHA	6389	3.020449	-0.214674	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DUOXA2	405753	2.028902	-0.423959	NaN	True	True
ACH-001524	skin_squamous	OTULINL	54491	2.007874	-0.281117	NaN	False	True
ACH-001554	eye_uveal_melanoma	ADGRB1	575	2.701722	-0.024443	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CABP4	57010	2.566798	-0.381660	NaN	True	True
ACH-001524	skin_squamous	TRIO	7204	2.007874	-0.183175	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	SLC29A1	2030	2.060374	-0.206295	NaN	False	True
ACH-001523	skin_squamous	TTC33	23548	2.680006	-0.304846	NaN	True	True
ACH-001524	skin_squamous	MED10	84246	2.007874	-0.604085	NaN	False	True
ACH-001554	eye_uveal_melanoma	EFR3A	23167	2.701722	-0.230020	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	AARS2	57505	2.060374	-0.648815	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CEP126	57562	6.241215	-0.362488	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	C6orf226	441150	2.060374	-0.556413	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GABPB1	2553	2.028902	-0.290718	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	TRIM39	56658	2.145172	-0.274077	NaN	False	True
ACH-001554	eye_uveal_melanoma	BHLHE22	27319	2.267856	-0.001170	NaN	False	False
ACH-001524	skin_squamous	MARCH6	10299	2.007874	-0.113797	NaN	False	True
ACH-001554	eye_uveal_melanoma	ADAM7	8756	2.267856	-0.061221	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	MRGPRF	116535	2.454952	-0.024535	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	C22orf15	150248	2.543976	-0.365240	NaN	False	True
ACH-000277	breast_HER2Amp	PGAP3	93210	17.438657	-0.231848	NaN	False	True
ACH-001554	eye_uveal_melanoma	TSPYL5	85453	2.701722	-0.942018	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SPG11	80208	2.028902	-0.017472	NaN	False	True
ACH-001523	skin_squamous	BRIX1	55299	3.020449	-0.657255	NaN	True	True
ACH-001554	eye_uveal_melanoma	RPL8	6132	2.701722	-1.431894	NaN	False	True
ACH-001523	skin_squamous	IRX2	153572	3.020449	-0.001187	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CTDSPL2	51496	2.028902	-0.409338	NaN	False	True
ACH-000280	ovary_non_epithelial	FYB2	199920	3.466104	-0.186261	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MMP10	4319	2.482392	-0.225603	NaN	True	True
ACH-000025	central_nervous_system_meningioma	CHGB	1114	14.136960	-0.088903	NaN	True	True
ACH-001554	eye_uveal_melanoma	PLEC	5339	2.701722	-0.241999	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TMEM134	80194	2.566798	-0.050598	NaN	False	True
ACH-001554	eye_uveal_melanoma	EEF1D	1936	2.701722	-0.262398	NaN	True	True
ACH-001523	skin_squamous	DAP	1611	3.020449	-0.193941	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	P2RY2	5029	2.616111	-0.229203	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	SUMF2	25870	4.556424	-0.035605	NaN	False	True
ACH-001521	skin_squamous	LPCAT1	79888	2.355673	-0.019698	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	DHX16	8449	2.145172	-1.083743	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	BIRC2	329	6.241215	-0.365435	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DYNC2H1	79659	2.482392	-0.040206	NaN	True	True
ACH-001524	skin_squamous	RPL37	6167	2.007874	-1.616054	NaN	False	True
ACH-001554	eye_uveal_melanoma	DEFB135	613209	2.267856	-0.042673	NaN	False	False
ACH-001554	eye_uveal_melanoma	MTSS1	9788	2.701722	-0.180662	NaN	True	True
ACH-001524	skin_squamous	BRIX1	55299	2.007874	-0.924117	NaN	True	True
ACH-001554	eye_uveal_melanoma	SPHK1	8877	2.027413	-0.112400	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MAML2	84441	2.622517	-0.070931	NaN	True	True
ACH-001554	eye_uveal_melanoma	AANAT	15	2.027413	-0.176263	NaN	False	True
ACH-001524	skin_squamous	ZFR	51663	2.007874	-0.022084	NaN	True	True
ACH-001554	eye_uveal_melanoma	ST3GAL1	6482	2.701722	-0.204364	NaN	True	True
ACH-001554	eye_uveal_melanoma	CSPP1	79848	2.267856	-0.100430	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	IDH3B	3420	2.502885	-0.042076	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	VOPP1	81552	4.556424	-0.511639	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PPARGC1A	10891	3.286798	-0.172888	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ZNF680	340252	2.955719	-0.742039	NaN	True	True
ACH-001523	skin_squamous	CTNND2	1501	3.020449	-0.013737	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RPS3	6188	2.677035	-0.818552	NaN	False	True
ACH-001554	eye_uveal_melanoma	NDUFAF6	137682	2.701722	-0.130521	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	COX4I1	1327	3.247461	-0.201338	NaN	False	True
ACH-001521	skin_squamous	PLEKHG4B	153478	2.869776	-0.499284	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FADD	8772	2.775982	-0.351626	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	THRSP	7069	2.677035	-0.193765	NaN	False	True
ACH-001554	eye_uveal_melanoma	TSTA3	7264	2.701722	-0.057571	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PRPH2	5961	2.060374	-0.314873	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SQOR	58472	2.028902	-0.251540	NaN	True	True
ACH-001554	eye_uveal_melanoma	FAM83A	84985	2.701722	-0.082575	NaN	True	True
ACH-001554	eye_uveal_melanoma	C8orf88	100127983	2.267856	-0.197282	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MED17	9440	2.622517	-0.881771	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FOLR3	2352	2.775982	-0.418262	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ATF1	466	3.885227	-0.441272	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DLG2	1740	2.677035	-0.104647	NaN	True	True
ACH-001524	skin_squamous	NUP155	9631	2.007874	-0.687043	NaN	True	True
ACH-001554	eye_uveal_melanoma	LY6K	54742	2.701722	-0.279272	NaN	True	True
ACH-001554	eye_uveal_melanoma	CPNE3	8895	2.267856	-0.038346	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TMEM126B	55863	2.677035	-0.036784	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	C22orf31	25770	2.612317	-0.035738	NaN	False	True
ACH-001554	eye_uveal_melanoma	CPSF1	29894	2.701722	-1.132829	NaN	False	True
ACH-000025	central_nervous_system_meningioma	FASTKD5	60493	14.136960	-0.269485	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CLCF1	23529	2.566798	-0.036868	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PPP6R3	55291	2.454952	-0.363052	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DNAJB13	374407	2.616111	-0.268210	NaN	True	True
ACH-001554	eye_uveal_melanoma	CA8	767	2.267856	-0.034077	NaN	False	True
ACH-000025	central_nervous_system_meningioma	FGD1	2245	5.051108	NaN	-0.570920	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TCIRG1	10312	2.454952	-0.262175	NaN	True	True
ACH-001524	skin_squamous	SELENOP	6414	2.007874	-0.093867	NaN	False	True
ACH-001524	skin_squamous	NDUFS6	4726	2.007874	-0.006920	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MYEOV	26579	2.454952	-0.152174	NaN	True	True
ACH-000248	breast_HER2Amp	MIEN1	84299	9.627685	-0.351978	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	EBF4	57593	2.502885	-0.019205	NaN	False	True
ACH-001524	skin_squamous	CARD6	84674	2.007874	-0.124452	NaN	False	True
ACH-001523	skin_squamous	SKP2	6502	3.020449	-0.617962	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	LALBA	3906	3.650199	-0.013448	NaN	False	False
ACH-000280	ovary_non_epithelial	APOE	348	2.085358	-0.137316	-0.100882	False	True
ACH-001328	skin_epidermoid_carcinoma	GUCA1A	2978	2.060374	-0.414951	NaN	True	False
ACH-001328	skin_epidermoid_carcinoma	MDC1	9656	2.145172	-0.402287	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CHCHD10	400916	2.543976	-0.206287	NaN	False	True
ACH-001554	eye_uveal_melanoma	YWHAZ	7534	2.701722	-0.192012	NaN	False	True
ACH-001554	eye_uveal_melanoma	PSKH2	85481	2.267856	-0.199200	NaN	True	False
ACH-001554	eye_uveal_melanoma	C8orf82	414919	2.701722	-0.209897	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PRCP	5547	2.677035	-0.235351	NaN	True	True
ACH-001554	eye_uveal_melanoma	MROH1	727957	2.701722	-0.207946	NaN	False	True
ACH-001554	eye_uveal_melanoma	COMMD5	28991	2.701722	-0.244150	NaN	False	True
ACH-000280	ovary_non_epithelial	OR4K1	79544	2.776707	-0.471690	NaN	True	False
ACH-001554	eye_uveal_melanoma	ZDHHC2	51201	2.267856	-0.111084	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	C11orf24	53838	2.454952	-0.176043	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PLA2G4D	283748	2.039894	-0.248401	NaN	False	True
ACH-001554	eye_uveal_melanoma	MRPL15	29088	2.267856	-0.784683	NaN	False	True
ACH-001523	skin_squamous	SRD5A1	6715	3.020449	-0.170075	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TMOD2	29767	2.028902	-0.048854	NaN	True	True
ACH-001521	skin_squamous	WDR70	55100	2.138119	-0.518490	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TNRC6C	57690	3.115341	-0.299195	NaN	True	True
ACH-001554	eye_uveal_melanoma	ERICH5	203111	2.701722	-0.360138	NaN	False	False
ACH-000280	ovary_non_epithelial	HECTD1	25831	2.050516	-0.992913	-0.061496	True	True
ACH-001328	skin_epidermoid_carcinoma	PPFIA1	8500	9.236191	-0.316739	NaN	True	True
ACH-001554	eye_uveal_melanoma	NRBP2	340371	2.701722	-0.097302	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RAD51	5888	2.039894	-0.693233	NaN	True	True
ACH-001554	eye_uveal_melanoma	ATP6V1H	51606	2.267856	-0.742139	NaN	False	True
ACH-000248	breast_HER2Amp	TCAP	8557	9.627685	-0.138830	-0.031669	False	True
ACH-001554	eye_uveal_melanoma	ZNF705B	100132396	2.267856	-0.235236	NaN	False	False
ACH-001328	skin_epidermoid_carcinoma	PPP1R10	5514	2.145172	-1.072720	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	PPP1R18	170954	2.145172	-0.260076	NaN	False	True
ACH-001554	eye_uveal_melanoma	DEFB136	613210	2.267856	-0.043922	NaN	False	False
ACH-000277	breast_HER2Amp	MIEN1	84299	17.438657	-1.138178	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MCM3	4172	2.060374	-0.715698	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SPTBN5	51332	2.039894	-0.121732	NaN	True	True
ACH-000711	breast_HER2Amp	PNMT	5409	7.195136	-0.125013	-0.091701	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CRYBB3	1417	3.253533	-0.384594	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PKHD1	5314	2.060374	-0.280288	NaN	True	False
ACH-001521	skin_squamous	ZDHHC11B	653082	2.869776	-0.082063	NaN	False	True
ACH-001554	eye_uveal_melanoma	SPIDR	23514	2.267856	-0.061674	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ZNF70	7621	2.543976	-0.097442	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	CUL9	23113	2.060374	-0.265470	NaN	True	True
ACH-001554	eye_uveal_melanoma	LETM2	137994	2.267856	-0.010860	NaN	True	True
ACH-001521	skin_squamous	RPL37	6167	2.138119	-1.763617	NaN	False	True
ACH-000280	ovary_non_epithelial	FGGY	55277	3.466104	-0.342802	0.078683	True	True
ACH-001956	bone_chordoma	PTRH1	138428	2.944848	-0.065413	NaN	False	False
ACH-001554	eye_uveal_melanoma	BRF2	55290	2.267856	-1.517202	NaN	False	True
ACH-001523	skin_squamous	WDR70	55100	2.680006	-0.382973	NaN	False	True
ACH-000277	breast_HER2Amp	STARD3	10948	17.438657	-0.418987	-0.324913	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ZNRF3	84133	2.612317	-0.175698	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TRPM7	54822	2.028902	-0.402612	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NEU3	10825	2.677035	-0.179328	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SERF2	10169	2.028902	-0.329445	NaN	False	True
ACH-001554	eye_uveal_melanoma	SLC52A2	79581	2.701722	-0.224169	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ANKRD49	54851	2.622517	-0.834057	NaN	True	True
ACH-000711	breast_HER2Amp	TCAP	8557	7.195136	-0.153291	-0.213327	False	True
ACH-001554	eye_uveal_melanoma	LACTB2	51110	2.267856	-0.072665	NaN	False	True
ACH-001554	eye_uveal_melanoma	POLR2K	5440	2.701722	-0.933884	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SMCO4	56935	2.991123	-0.023584	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	VEGFA	7422	2.060374	-0.041532	NaN	True	True
ACH-000025	central_nervous_system_meningioma	ITIH6	347365	5.051108	NaN	NaN	False	False
ACH-001521	skin_squamous	NSUN2	54888	2.355673	-0.400874	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GRM5	2915	2.677035	-0.197077	NaN	True	True
ACH-001524	skin_squamous	SDHA	6389	2.061718	-0.358738	NaN	False	True
ACH-001524	skin_squamous	TPPP	11076	2.061718	-0.233137	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	COA4	51287	2.616111	-0.259188	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PLA2G7	7941	2.060374	-0.148388	NaN	True	True
ACH-001554	eye_uveal_melanoma	MTERF3	51001	2.701722	-0.172444	NaN	False	True
ACH-000859	breast_HER2Amp	IKZF3	22806	54.124990	-0.148200	-0.081708	True	True
ACH-001554	eye_uveal_melanoma	AARD	441376	2.701722	-0.196662	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MMP7	4316	2.482392	-0.133631	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KCNE3	10008	2.677035	-0.153262	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	EVL	51466	3.677540	-0.061472	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CLNS1A	1207	2.677035	-1.169777	NaN	False	True
ACH-001524	skin_squamous	DNAH5	1767	2.007874	-0.533203	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	ELOVL5	60481	2.060374	-0.017191	NaN	False	True
ACH-001554	eye_uveal_melanoma	FGF20	26281	2.267856	-0.043566	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	KDM4D	55693	2.622517	-0.077920	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	ATAT1	79969	2.145172	-0.169346	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	ABCF1	23	2.145172	-0.776595	NaN	True	True
ACH-001554	eye_uveal_melanoma	MTMR9	66036	2.267856	-0.304449	NaN	True	True
ACH-000025	central_nervous_system_meningioma	PFKFB1	5207	5.051108	NaN	0.140204	False	True
ACH-001554	eye_uveal_melanoma	INTS10	55174	2.267856	-0.573301	NaN	True	True
ACH-001521	skin_squamous	AMACR	23600	2.138119	-0.070337	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	BYSL	705	2.060374	-1.038544	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CARD17	440068	2.482392	-0.122721	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	ADGRF4	221393	2.060374	-0.127420	NaN	True	True
ACH-001554	eye_uveal_melanoma	RBIS	401466	2.267856	-0.284228	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	B3GNT6	192134	2.677035	-0.230867	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DUOXA1	90527	2.028902	-0.059367	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ARPP19	10776	2.028902	-0.308358	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	AQR	9716	4.385107	-0.937719	NaN	True	True
ACH-000280	ovary_non_epithelial	OR4Q3	441669	2.776707	-0.019732	NaN	True	False
ACH-000054	soft_tissue_fibrosarcoma	TERT	7015	2.403867	-0.244190	-0.150555	False	True
ACH-001554	eye_uveal_melanoma	CYHR1	50626	2.701722	-0.442582	NaN	False	True
ACH-001521	skin_squamous	IL7R	3575	2.138119	-0.149621	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CABIN1	23523	2.543976	-0.206083	NaN	False	True
ACH-001554	eye_uveal_melanoma	IMPA1	3612	2.267856	-0.020831	NaN	False	True
ACH-001521	skin_squamous	UBE2QL1	134111	2.355673	-0.034720	NaN	False	False
ACH-001328	skin_epidermoid_carcinoma	GSTA2	2939	2.060374	-0.313121	NaN	True	False
ACH-001554	eye_uveal_melanoma	LYPD2	137797	2.701722	-0.218105	NaN	False	False
ACH-001554	eye_uveal_melanoma	ELP3	55140	2.267856	-1.108201	NaN	True	True
ACH-000711	breast_HER2Amp	STARD3	10948	7.195136	-0.189035	-0.139704	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	HPS4	89781	2.035225	-0.165850	NaN	False	True
ACH-001554	eye_uveal_melanoma	PARP10	84875	2.701722	-0.399541	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KRTAP5-10	387273	2.775982	-0.120284	NaN	False	True
ACH-001554	eye_uveal_melanoma	FNTA	2339	2.267856	-0.747358	NaN	False	True
ACH-000711	breast_HER2Amp	ERBB2	2064	7.195136	-0.312426	-0.061091	True	True
ACH-001328	skin_epidermoid_carcinoma	ZNF713	349075	4.556424	-0.061754	NaN	True	True
ACH-000280	ovary_non_epithelial	JUN	3725	3.466104	-0.983294	-0.235820	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GCHFR	2644	2.039894	-0.107156	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FGF19	9965	2.454952	-0.134356	NaN	False	True
ACH-001554	eye_uveal_melanoma	ZNF34	80778	2.701722	-0.218773	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MRGPRD	116512	2.454952	-0.202991	NaN	False	False
ACH-001521	skin_squamous	PDZD2	23037	2.138119	-0.004515	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	COPS2	9318	2.028902	-0.457547	NaN	False	True
ACH-001524	skin_squamous	PRLR	5618	2.007874	-0.109222	NaN	True	True
ACH-001524	skin_squamous	CMBL	134147	2.007874	-0.145308	NaN	False	True
ACH-000280	ovary_non_epithelial	APOC1	341	2.085358	-0.680341	NaN	False	True
ACH-001554	eye_uveal_melanoma	FAM86B1	85002	2.267856	-0.803192	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	ANO1	55107	4.080429	-0.202049	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	TFAP2B	7021	2.060374	-0.031111	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	PDGFD	80310	2.482392	-0.093259	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	ADGRF1	266977	2.060374	-0.093092	NaN	True	True
ACH-001554	eye_uveal_melanoma	CYC1	1537	2.701722	-0.847452	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	EIF3J	8669	2.028902	-0.374383	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ITPKA	3706	2.039894	-0.502310	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	DLK2	65989	2.060374	-0.241181	NaN	False	True
ACH-001523	skin_squamous	NSUN2	54888	3.020449	-0.044967	NaN	True	True
ACH-001554	eye_uveal_melanoma	TOP1MT	116447	2.701722	-0.148296	NaN	True	True
ACH-000277	breast_HER2Amp	NEUROD2	4761	17.438657	-0.556783	-0.007501	False	True
ACH-001554	eye_uveal_melanoma	RNF170	81790	2.267856	-0.140880	NaN	False	True
ACH-001521	skin_squamous	SKP2	6502	2.138119	-0.453850	NaN	False	True
ACH-000025	central_nervous_system_meningioma	NOP56	10528	14.136960	-1.029342	NaN	True	True
ACH-001554	eye_uveal_melanoma	THEM6	51337	2.701722	-0.228227	NaN	False	True
ACH-001554	eye_uveal_melanoma	DPY19L4	286148	2.701722	-0.019981	NaN	False	True
ACH-001521	skin_squamous	FASTKD3	79072	2.355673	-0.122921	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	DOK7	285489	4.104590	-0.143302	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	C6orf141	135398	2.060374	-0.235686	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RELT	84957	2.616111	-0.235993	NaN	True	True
ACH-001521	skin_squamous	CARD6	84674	2.138119	-0.040394	NaN	False	True
ACH-001524	skin_squamous	ANXA2R	389289	2.007874	-0.067284	NaN	False	True
ACH-000725	breast_HER2Amp	MIEN1	84299	9.359315	-0.063013	NaN	True	True
ACH-001523	skin_squamous	PDCD6	10016	3.020449	-0.641238	NaN	False	True
ACH-001521	skin_squamous	CPLANE1	65250	2.138119	-0.276440	NaN	True	True
ACH-000725	breast_HER2Amp	PGAP3	93210	9.359315	-0.301140	-0.195293	False	True
ACH-001521	skin_squamous	SUB1	10923	2.138119	-0.472030	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	EMC8	10328	3.247461	-0.193142	NaN	False	True
ACH-000280	ovary_non_epithelial	OR4M1	441670	2.776707	-0.015598	NaN	True	False
ACH-001524	skin_squamous	PDCD6	10016	2.061718	-1.053084	NaN	False	True
ACH-001554	eye_uveal_melanoma	GSDMD	79792	2.701722	-0.053808	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	FGF19	9965	4.080429	-0.072966	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ARHGEF17	9828	2.616111	-0.221236	NaN	True	True
ACH-001524	skin_squamous	IL7R	3575	2.007874	-0.002095	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	VPREB3	29802	2.543976	-0.058758	NaN	False	True
ACH-001521	skin_squamous	TTC33	23548	2.138119	-0.337478	NaN	True	True
ACH-001554	eye_uveal_melanoma	BOP1	23246	2.701722	-1.058951	NaN	False	True
ACH-000025	central_nervous_system_meningioma	TSR2	90121	5.051108	NaN	NaN	False	True
ACH-001554	eye_uveal_melanoma	VCPIP1	80124	2.267856	-0.524751	NaN	True	True
ACH-001523	skin_squamous	NIPBL	25836	2.680006	-0.096629	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	GSTA4	2941	2.060374	-0.035884	NaN	True	True
ACH-001554	eye_uveal_melanoma	EIF3E	3646	2.701722	-1.164982	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	NSMCE4A	54780	3.390253	-0.805022	NaN	False	True
ACH-001524	skin_squamous	TARS	6897	2.007874	-1.274878	NaN	False	True
ACH-001554	eye_uveal_melanoma	TG	7038	2.701722	-0.054325	NaN	True	True
ACH-001554	eye_uveal_melanoma	UBE2V2	7336	2.267856	-0.139512	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GGT1	2678	3.253533	-0.327264	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NDUFS8	4728	2.454952	-0.329411	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PRICKLE4	29964	2.060374	-0.188214	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MEA1	4201	2.060374	-0.369526	NaN	False	True
ACH-000711	breast_HER2Amp	IKZF3	22806	7.195136	-0.150406	-0.154820	True	True
ACH-001523	skin_squamous	NUP155	9631	2.680006	-0.500694	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	SLC6A5	9152	3.700540	-0.283188	NaN	True	True
ACH-000280	ovary_non_epithelial	TBC1D3B	414059	5.744172	-1.832195	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SUSD2	56241	2.543976	-0.368960	NaN	False	True
ACH-001554	eye_uveal_melanoma	FABP5	2171	2.267856	-0.420115	NaN	False	True
ACH-001554	eye_uveal_melanoma	RB1CC1	9821	2.267856	-0.309710	NaN	True	True
ACH-001523	skin_squamous	AGXT2	64902	3.020449	-0.125115	NaN	True	False
ACH-001554	eye_uveal_melanoma	GRHL2	79977	2.701722	-0.113801	NaN	True	False
ACH-000025	central_nervous_system_meningioma	TMEM230	29058	14.136960	-0.042591	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	MRPS17	51373	4.556424	-0.128069	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PRR3	80742	2.145172	-0.422725	NaN	False	True
ACH-001523	skin_squamous	MTMR12	54545	3.020449	-0.025606	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CHRDL2	25884	2.677035	-0.133296	NaN	False	False
ACH-001328	skin_epidermoid_carcinoma	DDR1	780	2.145172	-0.231579	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	HSP90AB1	3326	2.060374	-0.612285	NaN	True	True
ACH-001554	eye_uveal_melanoma	GRINA	2907	2.701722	-0.360823	NaN	True	True
ACH-001521	skin_squamous	UGT3A2	167127	2.138119	-0.115558	NaN	True	False
ACH-001554	eye_uveal_melanoma	CHMP4C	92421	2.267856	-0.046715	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	VEGFA	7422	2.195257	-0.266984	NaN	True	True
ACH-001523	skin_squamous	ZDHHC11	79844	3.020449	-0.024486	NaN	False	True
ACH-001554	eye_uveal_melanoma	TMEM249	340393	2.701722	-0.023110	NaN	False	True
ACH-001554	eye_uveal_melanoma	MFSD3	113655	2.701722	-0.127552	NaN	False	True
ACH-000248	breast_HER2Amp	ERBB2	2064	9.627685	-0.814894	-0.828721	True	True
ACH-001554	eye_uveal_melanoma	LY96	23643	2.267856	-0.004603	NaN	True	True
ACH-001523	skin_squamous	PTGER4	5734	2.680006	-0.028417	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	BDP1	55814	2.178864	-0.307029	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	IGLL5	100423062	2.921919	-0.044216	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CASC4	113201	2.028902	-0.017983	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	RUNX2	860	2.060374	-0.063117	NaN	False	True
ACH-001521	skin_squamous	CEP72	55722	2.869776	-0.164237	NaN	False	True
ACH-001554	eye_uveal_melanoma	ZNF250	58500	2.701722	-0.201364	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	CCND1	595	4.080429	-1.090322	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TOR4A	54863	3.124374	-0.394534	NaN	False	True
ACH-000025	central_nervous_system_meningioma	GNL3L	54552	5.051108	NaN	NaN	False	True
ACH-001554	eye_uveal_melanoma	KHDRBS3	10656	2.701722	-0.201688	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	UNC45B	146862	4.008782	-0.820893	NaN	True	True
ACH-000017	breast_HER2Amp	MIEN1	84299	10.553327	-0.584553	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	YAP1	10413	6.241215	-0.361408	NaN	True	True
ACH-001554	eye_uveal_melanoma	CCNE2	9134	2.701722	-0.013314	NaN	False	True
ACH-001524	skin_squamous	CDH18	1016	2.007874	-0.046851	NaN	True	True
ACH-001554	eye_uveal_melanoma	SLC20A2	6575	2.267856	-0.210309	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	FRS3	10817	2.060374	-0.525828	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	P2RY6	5031	2.616111	-0.587107	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MAP6	4135	2.677035	-0.156818	NaN	False	True
ACH-001523	skin_squamous	C5orf49	134121	3.020449	-0.185356	NaN	True	True
ACH-001554	eye_uveal_melanoma	PCM1	5108	2.267856	-0.151163	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PPP1CA	5499	2.566798	-0.884796	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	DTX1	1840	3.221726	-0.052351	NaN	True	True
ACH-001523	skin_squamous	MRPL36	64979	3.020449	-0.504707	NaN	False	True
ACH-000017	breast_HER2Amp	PPP1R1B	84152	10.553327	-0.408380	-0.100085	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DDTL	100037417	2.543976	-0.518846	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	BLID	414899	5.037434	-0.813330	NaN	False	True
ACH-000025	central_nervous_system_meningioma	VPS16	64601	14.136960	-0.160902	-0.158021	True	True
ACH-000277	breast_HER2Amp	IKZF3	22806	17.438657	-0.147724	-0.056701	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RPS6KB2	6199	2.566798	-0.136348	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	NLE1	54475	4.008782	-1.039929	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	EGFR	1956	4.556424	-0.557435	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SNRPD3	6634	3.253533	-0.897232	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PGR	5241	6.241215	-0.202713	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	DRICH1	51233	2.543976	-0.160288	NaN	False	True
ACH-001523	skin_squamous	CDH9	1007	3.020449	-0.122021	NaN	True	True
ACH-000280	ovary_non_epithelial	OR4K2	390431	2.776707	-0.078311	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	NUMA1	4926	2.775982	-0.536631	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MAP1A	4130	2.028902	-0.330867	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	CTTN	2017	9.236191	-0.327800	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SPCS2	9789	2.677035	-0.654595	NaN	False	True
ACH-001554	eye_uveal_melanoma	KLF10	7071	2.701722	-0.224693	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	CHCHD2	51142	4.556424	-0.581525	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TAF8	129685	2.060374	-0.833867	NaN	False	True
ACH-000711	breast_HER2Amp	PGAP3	93210	7.195136	-0.302584	-0.074137	False	True
ACH-001328	skin_epidermoid_carcinoma	MRPS18B	28973	2.145172	-0.715087	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	INO80	54617	2.039894	-0.535114	NaN	True	True
ACH-001554	eye_uveal_melanoma	PTP4A3	11156	2.701722	-0.130537	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TMIGD2	126259	3.688888	-0.048729	NaN	True	True
ACH-001554	eye_uveal_melanoma	FOXH1	8928	2.701722	-0.002753	NaN	False	True
ACH-001554	eye_uveal_melanoma	DEFB4A	1673	2.267856	-0.028118	NaN	False	False
ACH-001554	eye_uveal_melanoma	HSF1	3297	2.701722	-0.841877	NaN	True	True
ACH-001523	skin_squamous	ZNF622	90441	3.020449	-0.090101	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TENM4	26011	2.677035	-0.096981	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	GNL1	2794	2.145172	-0.410378	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PPME1	51400	2.691717	-0.467857	NaN	True	True
ACH-001521	skin_squamous	BRD9	65980	2.869776	-0.029944	NaN	True	True
ACH-001554	eye_uveal_melanoma	OTUD6B	51633	2.267856	-0.077445	NaN	False	True
ACH-001554	eye_uveal_melanoma	EXOSC4	54512	2.701722	-0.946045	NaN	False	True
ACH-000025	central_nervous_system_meningioma	APEX2	27301	3.549461	NaN	0.128141	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	CDKAL1	54901	2.559800	-0.208530	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DMXL2	23312	2.028902	-0.092584	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KRTAP5-9	3846	2.775982	-0.620502	NaN	False	True
ACH-001524	skin_squamous	TTC33	23548	2.007874	-0.048420	NaN	True	True
ACH-001521	skin_squamous	MRPS30	10884	2.397010	-0.516365	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GAL	51083	2.454952	-0.298110	NaN	False	True
ACH-001521	skin_squamous	BRIX1	55299	2.138119	-0.822359	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	STOX1	219736	3.318214	-0.047822	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PAQR8	85315	2.060374	-0.384719	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TOMM6	100188893	2.060374	-0.287762	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	P4HA3	283208	2.691717	-0.231361	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GRK3	157	3.253533	-0.310191	NaN	False	True
ACH-001524	skin_squamous	FBXL7	23194	2.007874	-0.128118	NaN	True	False
ACH-001524	skin_squamous	ANKRD33B	651746	2.007874	-0.215492	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	YIPF3	25844	2.060374	-0.102723	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CHP1	11261	2.039894	-0.294912	NaN	False	True
ACH-000017	breast_HER2Amp	IKZF3	22806	10.553327	-0.366744	-0.192702	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	KIAA0895	23366	3.910619	-0.198994	NaN	False	True
ACH-001524	skin_squamous	ICE1	23379	2.007874	-0.753152	NaN	False	True
ACH-001554	eye_uveal_melanoma	PRDM14	63978	2.267856	-0.263240	NaN	True	False
ACH-001554	eye_uveal_melanoma	MAPK15	225689	2.701722	-0.172644	NaN	True	True
ACH-001554	eye_uveal_melanoma	CHRAC1	54108	2.701722	-0.258977	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	XPA	7507	3.086173	-0.331365	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NDUFAF1	51103	2.039894	-0.494115	NaN	False	True
ACH-001554	eye_uveal_melanoma	ZNF705D	728957	2.267856	-0.117431	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	XRRA1	143570	2.677035	-0.269259	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KBTBD3	143879	2.482392	-0.253297	NaN	True	True
ACH-001554	eye_uveal_melanoma	TTI2	80185	2.267856	-0.803980	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	BLOC1S6	26258	2.028902	-0.186687	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ACY3	91703	2.843540	-0.013953	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ZNF548	147694	4.853024	-0.454331	NaN	False	True
ACH-001554	eye_uveal_melanoma	COPS5	10987	2.267856	-1.042858	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	GCM1	8521	2.060374	-0.062204	NaN	True	True
ACH-001554	eye_uveal_melanoma	MRPL13	28998	2.701722	-0.629467	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	UBR2	23304	2.060374	-0.503313	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	ADGRF5	221395	2.060374	-0.665707	NaN	True	False
ACH-000280	ovary_non_epithelial	HOOK1	51361	3.466104	-0.158911	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CASP1	834	2.482392	-0.087805	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SPATA5L1	79029	2.028902	-1.311502	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	FBXO9	26268	2.060374	-0.165955	NaN	True	True
ACH-001554	eye_uveal_melanoma	MYC	4609	2.701722	-1.855500	NaN	True	True
ACH-001523	skin_squamous	ZNF131	7690	2.680006	-0.661965	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CAPN5	726	2.677035	-0.312020	NaN	False	True
ACH-000280	ovary_non_epithelial	C1orf87	127795	3.466104	-0.079151	-0.058382	False	True
ACH-001523	skin_squamous	RPL37	6167	2.680006	-1.568463	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KRTAP5-8	57830	2.775982	-0.004387	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ANAPC15	25906	2.775982	-0.776714	NaN	False	True
ACH-001523	skin_squamous	DNAJC21	134218	3.020449	-0.130822	NaN	True	True
ACH-000248	breast_HER2Amp	PPP1R1B	84152	9.627685	-0.530466	0.040641	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	FANCD2	2177	2.577235	-1.023892	NaN	True	True
ACH-001554	eye_uveal_melanoma	NEFM	4741	2.267856	-0.057615	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	PEX6	5190	2.060374	-0.345829	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	HTN3	3347	4.335757	-0.087534	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	KLHDC3	116138	2.060374	-0.106817	NaN	True	True
ACH-000025	central_nervous_system_meningioma	ESF1	51575	14.136960	-0.745181	NaN	True	True
ACH-001524	skin_squamous	AHRR	57491	2.061718	-0.351071	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MRPL14	64928	2.060374	-0.738283	NaN	False	True
ACH-001521	skin_squamous	IRX1	79192	2.355673	-0.118112	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CCDC117	150275	2.612317	-0.282716	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DEFB131B	100129216	2.775982	-0.542457	NaN	False	False
ACH-001554	eye_uveal_melanoma	C8orf37	157657	2.701722	-0.080963	NaN	False	True
ACH-000277	breast_HER2Amp	PPP1R1B	84152	17.438657	-0.059223	0.055903	False	True
ACH-001554	eye_uveal_melanoma	SLC25A37	51312	2.267856	-0.283762	NaN	False	True
ACH-001554	eye_uveal_melanoma	RHPN1	114822	2.701722	-0.474897	NaN	True	True
ACH-001554	eye_uveal_melanoma	MBOAT4	619373	2.267856	-0.060260	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PAK1	5058	2.677035	-0.067344	NaN	True	True
ACH-001521	skin_squamous	ZNF622	90441	2.138119	-0.110072	NaN	False	True
ACH-000017	breast_HER2Amp	GRB7	2886	10.553327	-0.190768	-0.570171	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CRYBA4	1413	2.612317	-0.186721	NaN	True	True
ACH-001523	skin_squamous	CARD6	84674	2.680006	-0.024141	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TRAM2	9697	2.060374	-0.107762	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PDIA6	10130	3.738903	-0.523579	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MOGAT2	80168	2.677035	-0.015608	NaN	False	True
ACH-001554	eye_uveal_melanoma	DENND3	22898	2.701722	-0.061837	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ANTXRL	195977	3.874892	-0.227830	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	POLR1C	9533	2.060374	-1.645644	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	C6orf136	221545	2.145172	-0.343377	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	KIF7	374654	2.025996	-0.269513	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	WNT11	7481	2.677035	-0.173371	NaN	False	True
ACH-001554	eye_uveal_melanoma	RRS1	23212	2.267856	-1.232546	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CATSPER2	117155	2.028902	-0.046713	NaN	False	True
ACH-001521	skin_squamous	NIPBL	25836	2.138119	-0.890264	NaN	True	True
ACH-001523	skin_squamous	CEP72	55722	3.020449	-0.108813	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	RARS	5917	3.759011	-0.536070	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	SUPT3H	8464	2.060374	-0.090915	NaN	True	True
ACH-001554	eye_uveal_melanoma	RP1	6101	2.267856	-0.020313	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	SERINC4	619189	2.028902	-0.746484	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GAB2	9846	2.677035	-0.426927	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NDUFC2	4718	2.677035	-0.371764	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	EED	8726	2.677035	-0.313530	NaN	True	True
ACH-001521	skin_squamous	ICE1	23379	2.355673	-0.934903	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PTK7	5754	2.060374	-0.136664	NaN	False	True
ACH-001554	eye_uveal_melanoma	ZC3H3	23144	2.701722	-0.180800	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DUT	1854	2.028902	-1.399811	NaN	False	True
ACH-001521	skin_squamous	ZDHHC11	79844	2.869776	-0.384125	NaN	False	True
ACH-001521	skin_squamous	AGXT2	64902	2.138119	-0.030563	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	TBC1D10C	374403	2.566798	-0.313790	NaN	True	True
ACH-001554	eye_uveal_melanoma	NDUFB9	4715	2.701722	-0.559646	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	HGFAC	3083	4.104590	-0.194289	NaN	True	True
ACH-001524	skin_squamous	RAD1	5810	2.007874	-0.128550	NaN	True	True
ACH-001554	eye_uveal_melanoma	AZIN1	51582	2.701722	-0.295611	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CASP4	837	2.482392	-0.029702	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	IL18BP	10068	2.775982	-0.134972	NaN	False	True
ACH-001523	skin_squamous	MYO10	4651	3.020449	-0.135843	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TRIM69	140691	2.028902	-0.060743	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PITPNB	23760	2.612317	-0.047105	NaN	True	True
ACH-001554	eye_uveal_melanoma	RMDN1	51115	2.267856	-0.041308	NaN	False	True
ACH-001554	eye_uveal_melanoma	PIP4P2	55529	2.267856	-0.083504	NaN	True	True
ACH-001521	skin_squamous	HMGCS1	3157	2.397010	-0.261280	NaN	True	True
ACH-001524	skin_squamous	GDNF	2668	2.007874	-0.026821	NaN	True	False
ACH-001554	eye_uveal_melanoma	FZD3	7976	2.267856	-0.065339	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	BGLAP	632	3.316326	-0.248888	NaN	False	True
ACH-001554	eye_uveal_melanoma	FDFT1	2222	2.267856	-0.199835	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	SGCA	6442	3.404323	-0.420828	NaN	True	True
ACH-001524	skin_squamous	C5orf34	375444	2.007874	-0.006382	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	NUPR2	389493	4.556424	-0.373959	NaN	False	False
ACH-001554	eye_uveal_melanoma	GTF2E2	2961	2.267856	-0.719451	NaN	False	True
ACH-001521	skin_squamous	NUP155	9631	2.138119	-0.881802	NaN	True	True
ACH-000025	central_nervous_system_meningioma	WNK3	65267	5.051108	NaN	-0.032529	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	KATNA1	11104	3.764306	-0.216794	NaN	False	True
ACH-001524	skin_squamous	ANKH	56172	2.007874	-0.141619	NaN	True	True
ACH-001554	eye_uveal_melanoma	ERLIN2	11160	2.267856	-0.124426	NaN	False	True
ACH-001554	eye_uveal_melanoma	GML	2765	2.701722	-0.175452	NaN	False	False
ACH-001523	skin_squamous	MED10	84246	3.020449	-0.357021	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	CAPN11	11131	2.060374	-0.289192	NaN	True	False
ACH-001521	skin_squamous	CDH10	1008	2.138119	-0.280444	NaN	True	False
ACH-001164	soft_tissue_sarcoma_undifferentiated	CCAR1	55749	3.318214	-0.885877	NaN	True	True
ACH-001521	skin_squamous	NNT	23530	2.397010	-0.024863	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DNAJC17	55192	2.039894	-1.420843	NaN	False	True
ACH-001554	eye_uveal_melanoma	RIMS2	9699	2.701722	-0.200853	NaN	True	True
ACH-001554	eye_uveal_melanoma	PTK2	5747	2.701722	-0.502582	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ZNF705E	100131539	2.775982	-0.240539	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TAF1D	79101	2.622517	-0.563253	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	LRRC32	2615	2.677035	-0.365168	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	INPPL1	3636	2.775982	-0.159410	NaN	True	True
ACH-001554	eye_uveal_melanoma	C8orf76	84933	2.701722	-0.131765	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	NR2C1	7181	2.692126	-0.007473	NaN	True	True
ACH-001521	skin_squamous	ZNF131	7690	2.397010	-0.931689	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ZFYVE16	9765	2.585951	-0.074903	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PLA2G4F	255189	2.039894	-0.227210	NaN	True	True
ACH-001554	eye_uveal_melanoma	DNAJC5B	85479	2.267856	-0.159308	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RAB38	23682	2.677035	-0.082303	NaN	True	True
ACH-001521	skin_squamous	LIFR	3977	2.138119	-0.004491	NaN	True	True
ACH-001554	eye_uveal_melanoma	ATAD2	29028	2.701722	-0.011605	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CHORDC1	26973	2.991123	-0.740700	NaN	False	True
ACH-001523	skin_squamous	CDH6	1004	3.020449	-0.048571	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	SRF	6722	2.060374	-0.486550	NaN	False	True
ACH-000025	central_nervous_system_meningioma	SNRPB	6628	14.136960	-1.498102	-1.291640	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NUSAP1	51203	2.039894	-0.174001	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PICALM	8301	2.677035	-0.145448	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	CRISP1	167	2.060374	-0.157400	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	PDE2A	5138	2.775982	-0.112450	NaN	True	True
ACH-000280	ovary_non_epithelial	CEACAM19	56971	2.085358	-0.117888	NaN	False	True
ACH-001554	eye_uveal_melanoma	PEBP4	157310	2.267856	-0.043778	NaN	False	False
ACH-001554	eye_uveal_melanoma	ATP6V1B2	526	2.267856	-1.905621	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MRE11	4361	2.622517	-0.510062	NaN	True	True
ACH-001554	eye_uveal_melanoma	ARHGAP39	80728	2.701722	-0.001231	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	SLC25A27	9481	2.060374	-0.024281	NaN	False	True
ACH-000277	breast_HER2Amp	TCAP	8557	17.438657	-0.221450	-0.196024	False	True
ACH-001523	skin_squamous	CDH18	1016	3.020449	-0.002089	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	RRP36	88745	2.060374	-0.144606	NaN	False	True
ACH-000025	central_nervous_system_meningioma	TRO	7216	5.051108	NaN	-0.330488	False	True
ACH-001554	eye_uveal_melanoma	TGS1	96764	2.267856	-0.715316	NaN	True	True
ACH-001554	eye_uveal_melanoma	BAALC	79870	2.701722	-0.004809	NaN	True	True
ACH-001554	eye_uveal_melanoma	LRATD2	157638	2.701722	-0.076341	NaN	False	True
ACH-001523	skin_squamous	CDH12	1010	3.020449	-0.117746	NaN	True	True
ACH-001554	eye_uveal_melanoma	DERL1	79139	2.701722	-0.046795	NaN	False	True
ACH-000025	central_nervous_system_meningioma	SAT2	112483	2.136427	-0.145027	0.163372	False	True
ACH-001554	eye_uveal_melanoma	RPL7	6129	2.267856	-1.164725	NaN	False	True
ACH-001521	skin_squamous	AHRR	57491	2.869776	-0.649083	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ATP6V1G2	534	2.312995	-0.695490	NaN	False	True
ACH-001554	eye_uveal_melanoma	MCM4	4173	2.267856	-1.185054	NaN	True	True
ACH-001554	eye_uveal_melanoma	CPQ	10404	2.701722	-0.140581	NaN	True	True
ACH-001554	eye_uveal_melanoma	EMC2	9694	2.701722	-0.373772	NaN	True	True
ACH-000025	central_nervous_system_meningioma	ATP1B2	482	2.136427	-0.261983	NaN	False	True
ACH-001524	skin_squamous	SUB1	10923	2.007874	-0.030545	NaN	True	True
ACH-001523	skin_squamous	ATPSCKMT	134145	3.020449	-0.153527	NaN	False	True
ACH-001554	eye_uveal_melanoma	SAMD12	401474	2.701722	-0.062753	NaN	True	True
ACH-001523	skin_squamous	AHRR	57491	3.020449	-0.081354	NaN	True	True
ACH-001523	skin_squamous	ANKH	56172	3.020449	-0.036690	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	ICK	22858	2.060374	-0.160506	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TGFA	7039	3.442422	-0.241603	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	A1CF	29974	3.621974	-0.083654	NaN	True	False
ACH-001523	skin_squamous	NDUFS6	4726	3.020449	-0.216671	NaN	False	True
ACH-001554	eye_uveal_melanoma	EXTL3	2137	2.267856	-0.000613	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TPBGL	100507050	2.677035	-0.363317	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	CCDC81	60494	2.677035	-0.097585	NaN	True	True
ACH-001524	skin_squamous	CTNND2	1501	2.007874	-0.002104	NaN	True	True
ACH-001554	eye_uveal_melanoma	PRSS55	203074	2.267856	-0.044448	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	XBP1	7494	2.612317	-0.268955	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ANKRD62	342850	3.799925	-0.468883	NaN	False	False
ACH-001328	skin_epidermoid_carcinoma	CCND3	896	2.060374	-0.216014	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RNF169	254225	2.677035	-0.178523	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	VPS18	57617	2.039894	-1.053071	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PIWIL3	440822	3.253533	-0.472453	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DLL4	54567	2.039894	-0.133259	NaN	False	True
ACH-001523	skin_squamous	PLEKHG4B	153478	3.020449	-0.026697	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	KLHL31	401265	2.060374	-0.053956	NaN	True	True
ACH-000025	central_nervous_system_meningioma	SHLD1	149840	14.136960	-0.215533	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DHCR7	1717	2.775982	-0.149130	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	SDF2L1	23753	3.632521	-0.588982	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ALDH3B2	222	2.843540	-0.188682	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	CCDC88B	283234	3.252369	-0.659562	NaN	False	True
ACH-000280	ovary_non_epithelial	CEACAM16	388551	2.085358	-0.304742	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SPINT1	6692	2.039894	-0.293583	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	SEPTIN14	346288	4.556424	-0.187301	NaN	True	False
ACH-001328	skin_epidermoid_carcinoma	POLH	5429	2.060374	-0.422545	NaN	False	True
ACH-001554	eye_uveal_melanoma	TIGD5	84948	2.701722	-0.293601	NaN	False	True
ACH-001554	eye_uveal_melanoma	RBM12B	389677	2.701722	-0.246452	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ZFYVE19	84936	2.039894	-0.133630	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CAPN3	825	2.039894	-0.228589	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	BHLHA15	168620	4.195076	-0.519392	NaN	False	True
ACH-000280	ovary_non_epithelial	MYSM1	114803	3.466104	-0.359997	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CABP2	51475	2.566798	-0.124031	NaN	False	False
ACH-000025	central_nervous_system_meningioma	MRPS26	64949	14.136960	-0.462192	NaN	False	True
ACH-001521	skin_squamous	MYO10	4651	2.138119	-0.247391	NaN	True	True
ACH-001521	skin_squamous	MRPL36	64979	2.355673	-0.531533	NaN	False	True
ACH-001554	eye_uveal_melanoma	SCRT1	83482	2.701722	-0.381393	NaN	False	True
ACH-001521	skin_squamous	DAP	1611	2.355673	-0.361971	NaN	False	True
ACH-001521	skin_squamous	ANXA2R	389289	2.397010	-0.006675	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	SMG5	23381	3.316326	-1.397279	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	FADD	8772	9.236191	-0.329191	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	JMJD7	100137047	2.039894	-0.318323	NaN	False	True
ACH-001521	skin_squamous	LMBRD2	92255	2.138119	-0.089450	NaN	True	True
ACH-001554	eye_uveal_melanoma	TM2D2	83877	2.267856	-0.290058	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	INTS4	92105	2.677035	-0.947533	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GRIA4	2893	2.482392	-0.138489	NaN	True	True
ACH-000280	ovary_non_epithelial	PRKAA2	5563	3.466104	-0.464635	0.241197	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NARS2	79731	2.677035	-0.187801	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	TCTE1	202500	2.060374	-0.413717	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GANC	2595	2.039894	-0.244594	NaN	False	True
ACH-001554	eye_uveal_melanoma	MROH6	642475	2.701722	-0.151006	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	IER3	8870	2.145172	-0.432858	NaN	False	True
ACH-001521	skin_squamous	CCT5	22948	2.355673	-0.866448	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GALK2	2585	2.028902	-0.058826	NaN	False	True
ACH-001554	eye_uveal_melanoma	MRPS28	28957	2.267856	-0.385289	NaN	False	True
ACH-001554	eye_uveal_melanoma	ZNF703	80139	2.267856	-0.031869	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	HIKESHI	51501	2.677035	-0.340780	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PAQR6	79957	3.316326	-0.440318	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TMEM151B	441151	2.060374	-0.115311	NaN	False	True
ACH-001554	eye_uveal_melanoma	SQLE	6713	2.701722	-0.327143	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MAPK6	5597	2.028902	-0.224822	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	POLD3	10714	2.677035	-0.991704	NaN	True	True
ACH-001554	eye_uveal_melanoma	MTBP	27085	2.701722	-1.524139	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	PPP2R5D	5528	2.060374	-0.285928	NaN	False	True
ACH-000277	breast_HER2Amp	ERBB2	2064	17.438657	-1.351421	-1.271433	True	True
ACH-001521	skin_squamous	OTULIN	90268	2.138119	-0.331475	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	LANCL2	55915	4.556424	-0.148475	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	AAMDC	28971	2.677035	-0.233276	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PRPF38B	55119	2.492409	-1.526976	NaN	False	True
ACH-000280	ovary_non_epithelial	CCL3L3	414062	5.744172	-0.365616	0.042178	False	True
ACH-000859	breast_HER2Amp	PPP1R1B	84152	54.124990	-0.163979	-0.000578	False	True
ACH-000248	breast_HER2Amp	PGAP3	93210	9.627685	-0.528862	0.088909	False	True
ACH-000280	ovary_non_epithelial	TM2D1	83941	3.466104	-0.506120	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MRPL21	219927	2.454952	-1.507619	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	FUS	2521	2.797234	-0.297755	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DUOX1	53905	2.028902	-0.040992	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MYO7A	4647	2.677035	-0.182777	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TBR1	10716	4.172095	-0.196154	NaN	False	False
ACH-001523	skin_squamous	C9	735	2.680006	-0.124347	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	PTCRA	171558	2.060374	-0.286773	NaN	True	False
ACH-001554	eye_uveal_melanoma	AGO2	27161	2.701722	-0.204070	NaN	True	True
ACH-001554	eye_uveal_melanoma	OR4F21	441308	2.267856	-0.370244	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	SPECC1L	23384	2.543976	-0.107134	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	LTO1	220064	2.454952	-1.404487	NaN	False	True
ACH-001554	eye_uveal_melanoma	UBE2O	63893	2.027413	-0.346991	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MTNR1B	4544	2.991123	-0.001081	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	PANX1	24145	2.622517	-0.006297	NaN	False	True
ACH-001524	skin_squamous	MYO10	4651	2.007874	-0.057407	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NDUFV1	4723	2.475256	-0.253969	NaN	True	True
ACH-001521	skin_squamous	C5orf38	153571	2.355673	-0.134805	NaN	True	True
ACH-001554	eye_uveal_melanoma	WRN	7486	2.267856	-0.202646	NaN	True	True
ACH-001524	skin_squamous	DNAJC21	134218	2.007874	-0.316403	NaN	True	True
ACH-000280	ovary_non_epithelial	BCAM	4059	2.085358	-0.032809	NaN	False	True
ACH-001554	eye_uveal_melanoma	ATP6V1C1	528	2.701722	-0.659236	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	BRD3	8019	3.242162	-0.010365	NaN	False	True
ACH-001554	eye_uveal_melanoma	ZFHX4	79776	2.267856	-0.244680	NaN	True	True
ACH-001554	eye_uveal_melanoma	FAM83H	286077	2.701722	-0.367480	NaN	True	True
ACH-001521	skin_squamous	EXOC3	11336	2.869776	-0.536886	NaN	False	True
ACH-000025	central_nervous_system_meningioma	MAGED2	10916	5.051108	NaN	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	LTO1	220064	4.080429	-1.306797	NaN	False	True
ACH-001554	eye_uveal_melanoma	DSCC1	79075	2.701722	-0.384855	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	LRP5	4041	2.454952	-0.259472	NaN	True	True
ACH-000248	breast_HER2Amp	NEUROD2	4761	9.627685	-0.300023	0.089552	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FAM98B	283742	3.135840	-0.650940	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	COX15	1355	3.183798	-0.433136	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TSKU	25987	2.677035	-0.192502	NaN	False	True
ACH-001521	skin_squamous	FBXO4	26272	2.138119	-0.031243	NaN	False	True
ACH-000248	breast_HER2Amp	GRB7	2886	9.627685	-0.323955	-0.228634	False	True
ACH-001328	skin_epidermoid_carcinoma	RPL7L1	285855	2.060374	-0.656861	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	CCDC116	164592	3.632521	-0.389710	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	TMEM63B	55362	2.060374	-0.245621	NaN	True	True
ACH-001521	skin_squamous	DROSHA	29102	2.138119	-0.495400	NaN	True	True
ACH-001554	eye_uveal_melanoma	NAPRT	93100	2.701722	-0.268332	NaN	False	True
ACH-001554	eye_uveal_melanoma	KCNS2	3788	2.701722	-0.098498	NaN	True	True
ACH-001521	skin_squamous	ADAMTS16	170690	2.355673	-0.210280	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TMEM87A	25963	2.039894	-0.594654	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	EXD1	161829	2.039894	-0.125364	NaN	False	True
ACH-001554	eye_uveal_melanoma	EIF3H	8667	2.701722	-0.727671	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CDK2AP2	10263	2.566798	-0.588725	NaN	False	True
ACH-001524	skin_squamous	PTGER4	5734	2.007874	-0.101023	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MYO18B	84700	3.253533	-0.236620	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	EFHC1	114327	2.060374	-0.202572	NaN	True	True
ACH-001554	eye_uveal_melanoma	FAM110B	90362	2.267856	-0.019388	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	RIDA	10247	3.725001	-0.440433	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TTC27	55622	3.778776	-1.490666	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	NRM	11270	2.145172	-0.079304	NaN	False	True
ACH-000025	central_nervous_system_meningioma	PCNA	5111	14.136960	-1.617954	-0.630554	False	True
ACH-000280	ovary_non_epithelial	TOMM40	10452	2.085358	-1.286656	-0.670697	False	True
ACH-001523	skin_squamous	MARCH6	10299	3.020449	-0.204395	NaN	False	True
ACH-000017	breast_HER2Amp	TCAP	8557	10.553327	-0.367693	0.026090	False	True
ACH-001554	eye_uveal_melanoma	SMIM19	114926	2.267856	-0.040131	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GATM	2628	2.028902	-0.169598	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ERF	2077	3.447860	-0.418268	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	GUCA1B	2979	2.060374	-0.094983	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	SH3BGR	6450	2.186377	-0.057621	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SHC4	399694	2.028902	-0.142112	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TUBB	203068	2.145172	-1.670921	NaN	False	True
ACH-001554	eye_uveal_melanoma	NSMCE2	286053	2.701722	-0.406848	NaN	False	True
ACH-001554	eye_uveal_melanoma	CHMP7	91782	2.267856	-0.654589	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	HLA-E	3133	2.145172	-0.309356	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GGT5	2687	2.543976	-0.057242	NaN	True	True
ACH-000248	breast_HER2Amp	PNMT	5409	9.627685	-0.348810	0.075953	False	True
ACH-001554	eye_uveal_melanoma	TAF2	6873	2.701722	-0.549909	NaN	True	True
ACH-001554	eye_uveal_melanoma	ABRA	137735	2.701722	-0.027735	NaN	True	True
ACH-001521	skin_squamous	TPPP	11076	2.869776	-0.224711	NaN	False	True
ACH-000280	ovary_non_epithelial	USP1	7398	3.466104	-0.280363	-0.098994	False	True
ACH-001328	skin_epidermoid_carcinoma	IL17F	112744	2.060374	-0.182760	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	RTF1	23168	2.039894	-0.703992	NaN	True	True
ACH-001554	eye_uveal_melanoma	SHARPIN	81858	2.701722	-0.248717	NaN	True	True
ACH-001554	eye_uveal_melanoma	ASH2L	9070	2.267856	-0.216782	NaN	False	True
ACH-001521	skin_squamous	RICTOR	253260	2.138119	-0.495934	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	USP49	25862	2.060374	-0.380803	NaN	True	True
ACH-001521	skin_squamous	RAD1	5810	2.138119	-0.416696	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	SLC22A7	10864	2.060374	-0.211995	NaN	False	False
ACH-001554	eye_uveal_melanoma	GLI4	2738	2.701722	-0.462910	NaN	False	True
ACH-001523	skin_squamous	SLC12A7	10723	3.020449	-0.068784	NaN	False	True
ACH-001554	eye_uveal_melanoma	PCMTD1	115294	2.267856	-0.185809	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	AASDHPPT	60496	2.482392	-0.520912	NaN	True	True
ACH-000025	central_nervous_system_meningioma	TFRC	7037	4.422003	-1.343996	-0.552006	True	True
ACH-001523	skin_squamous	UBE2QL1	134111	3.020449	-0.053088	NaN	False	True
ACH-000025	central_nervous_system_meningioma	FAM120C	54954	5.051108	NaN	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KMT5B	51111	2.454952	-0.345885	NaN	True	True
ACH-001554	eye_uveal_melanoma	PPP2R2A	5520	2.267856	-0.483675	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RASGRP1	10125	3.135840	-0.225839	NaN	True	True
ACH-001521	skin_squamous	NPR3	4883	2.138119	-0.009144	NaN	True	True
ACH-001554	eye_uveal_melanoma	DCAF13	25879	2.701722	-0.083773	NaN	True	True
ACH-001554	eye_uveal_melanoma	IKBKB	3551	2.267856	-0.052874	NaN	False	True
ACH-001521	skin_squamous	UGT3A1	133688	2.138119	-0.155595	NaN	True	False
ACH-001524	skin_squamous	ATPSCKMT	134145	2.007874	-0.120390	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MAPKBP1	23005	2.039894	-0.219595	NaN	True	True
ACH-001521	skin_squamous	PRDM9	56979	2.138119	-0.224637	NaN	True	False
ACH-001554	eye_uveal_melanoma	TRIB1	10221	2.701722	-0.239068	NaN	True	True
ACH-001554	eye_uveal_melanoma	RPL30	6156	2.701722	-0.406293	NaN	False	True
ACH-001521	skin_squamous	RXFP3	51289	2.138119	-0.235838	NaN	True	False
ACH-000025	central_nervous_system_meningioma	ITPA	3704	14.136960	-0.009531	-0.237702	True	True
ACH-001523	skin_squamous	TRIO	7204	3.020449	-0.186260	NaN	True	True
ACH-001524	skin_squamous	TERT	7015	2.007874	-0.150692	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	SLC30A4	7782	2.028902	-0.031837	NaN	False	True
ACH-000280	ovary_non_epithelial	CBLC	23624	2.085358	-0.167906	0.012064	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PHOX2A	401	2.775982	-0.297120	NaN	False	True
ACH-000248	breast_HER2Amp	STARD3	10948	9.627685	-0.380292	-0.352616	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	KIAA1671	85379	3.253533	-0.024022	NaN	False	True
ACH-001554	eye_uveal_melanoma	PABPC1	26986	2.701722	-0.625849	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PSG11	5680	2.072998	-0.571963	NaN	True	False
ACH-001554	eye_uveal_melanoma	WASHC5	9897	2.701722	-0.341853	NaN	False	True
ACH-000025	central_nervous_system_meningioma	CFHR1	3078	2.356099	-0.105053	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	RSPH9	221421	2.060374	-0.264407	NaN	True	True
ACH-001554	eye_uveal_melanoma	SLURP1	57152	2.701722	-0.023714	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	USP35	57558	2.677035	-0.352009	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NUDT8	254552	2.475256	-0.271069	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	SLC35B2	347734	2.060374	-0.739419	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SECISBP2L	9728	2.028902	-0.144617	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	FSD1	79187	3.688888	-0.214734	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GLDN	342035	2.028902	-0.137613	NaN	False	True
ACH-001524	skin_squamous	LIFR	3977	2.007874	-0.098091	NaN	True	True
ACH-001523	skin_squamous	CCT5	22948	3.020449	-0.759139	NaN	False	True
ACH-001524	skin_squamous	NSUN2	54888	2.007874	-0.104161	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MFAP1	4236	2.028902	-1.043212	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	LRRC75B	388886	3.253533	-0.384063	NaN	False	True
ACH-001554	eye_uveal_melanoma	SFRP1	6422	2.267856	-0.087447	NaN	True	True
ACH-001554	eye_uveal_melanoma	DCTN6	10671	2.267856	-0.961361	NaN	False	True
ACH-001521	skin_squamous	PRKAA1	5562	2.138119	-0.075584	NaN	True	True
ACH-000017	breast_HER2Amp	ERBB2	2064	10.553327	-1.183709	-1.680262	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	USP8	9101	2.028902	-0.901063	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	XPO5	57510	2.060374	-1.164938	NaN	True	True
ACH-001554	eye_uveal_melanoma	DOK2	9046	2.267856	-0.000702	NaN	True	False
ACH-001521	skin_squamous	SLC9A3	6550	2.869776	-0.562310	NaN	True	True
ACH-001957	bone_chordoma	DENND1C	79958	2.545593	-0.030982	NaN	True	False
ACH-001554	eye_uveal_melanoma	NUDCD1	84955	2.701722	-0.092953	NaN	True	True
ACH-001554	eye_uveal_melanoma	VPS37A	137492	2.267856	-0.671342	NaN	False	True
ACH-001524	skin_squamous	PDZD2	23037	2.007874	-0.003934	NaN	True	True
ACH-001554	eye_uveal_melanoma	PRPSAP1	5635	2.027413	-0.033808	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TFEB	7942	2.060374	-0.226255	NaN	False	True
ACH-001524	skin_squamous	CDH12	1010	2.007874	-0.078904	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	AIP	9049	2.566798	-0.538169	NaN	False	True
ACH-001521	skin_squamous	PDCD6	10016	2.869776	-0.872874	NaN	False	True
ACH-001521	skin_squamous	CCL28	56477	2.397010	-0.123887	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	OPN5	221391	2.060374	-0.191150	NaN	False	False
ACH-001524	skin_squamous	PLEKHG4B	153478	2.061718	-0.298247	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PLA2G4B	100137049	2.039894	-0.107051	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CFAP300	85016	6.241215	-0.393075	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ASPHD2	57168	2.035225	-0.447836	NaN	True	True
ACH-001554	eye_uveal_melanoma	GSDMC	56169	2.701722	-0.098400	NaN	True	True
ACH-001554	eye_uveal_melanoma	MYOM2	9172	2.267856	-0.064094	NaN	True	True
ACH-001524	skin_squamous	DROSHA	29102	2.007874	-0.225914	NaN	True	True
ACH-000025	central_nervous_system_meningioma	CRLS1	54675	14.136960	-0.304441	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	RCAN2	10231	2.060374	-0.069163	NaN	False	True
ACH-001554	eye_uveal_melanoma	CCDC166	100130274	2.701722	-0.005786	NaN	False	False
ACH-001554	eye_uveal_melanoma	KCTD9	54793	2.267856	-0.081016	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CTTN	2017	2.775982	-0.362288	NaN	True	True
ACH-001524	skin_squamous	C5orf49	134121	2.007874	-0.142199	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RMDN3	55177	2.039894	-0.095944	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TJAP1	93643	2.060374	-0.171519	NaN	False	True
ACH-001554	eye_uveal_melanoma	TBC1D31	93594	2.701722	-0.151481	NaN	True	True
ACH-001554	eye_uveal_melanoma	CNOT7	29883	2.267856	-0.279055	NaN	True	True
ACH-001554	eye_uveal_melanoma	POP1	10940	2.701722	-0.698959	NaN	True	True
ACH-001554	eye_uveal_melanoma	STK3	6788	2.701722	-0.116804	NaN	True	True
ACH-001524	skin_squamous	ROPN1L	83853	2.007874	-0.449385	NaN	False	True
ACH-001956	bone_chordoma	AUTS2	26053	2.271553	-0.039982	NaN	False	False
ACH-001554	eye_uveal_melanoma	GPAA1	8733	2.701722	-0.056319	NaN	True	True
ACH-000280	ovary_non_epithelial	POTEG	404785	2.776707	-0.691269	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	MYEOV	26579	4.080429	-0.130247	NaN	True	True
ACH-001554	eye_uveal_melanoma	FER1L6	654463	2.701722	-0.007341	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	TERB2	145645	2.028902	-0.168923	NaN	False	False
ACH-001521	skin_squamous	MED10	84246	2.355673	-0.692751	NaN	False	True
ACH-000711	breast_HER2Amp	PPP1R1B	84152	7.195136	-0.288421	0.188300	False	True
ACH-000280	ovary_non_epithelial	NFIA	4774	3.466104	-0.641134	-0.214463	True	True
ACH-001523	skin_squamous	C5orf34	375444	2.680006	-0.220500	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	VCAN	1462	2.395578	-0.428611	NaN	True	True
ACH-000017	breast_HER2Amp	STARD3	10948	10.553327	-0.325511	-0.268501	False	True
ACH-001554	eye_uveal_melanoma	GDAP1	54332	2.267856	-0.050691	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ELL3	80237	2.028902	-0.298453	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MRPL2	51069	2.060374	-0.586253	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	TRERF1	55809	2.060374	-0.137719	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	SPATS1	221409	2.060374	-0.449526	NaN	False	False
ACH-001328	skin_epidermoid_carcinoma	ZNF318	24149	2.060374	-0.407193	NaN	True	True
ACH-001554	eye_uveal_melanoma	SNAI2	6591	2.267856	-0.113615	NaN	True	True
ACH-001523	skin_squamous	SLC9A3	6550	3.020449	-0.436823	NaN	True	True
ACH-001554	eye_uveal_melanoma	TRAPPC9	83696	2.701722	-0.178901	NaN	True	True
ACH-001554	eye_uveal_melanoma	CPA6	57094	2.267856	-0.079853	NaN	True	True
ACH-001554	eye_uveal_melanoma	PRCD	768206	2.027413	-0.003933	NaN	False	True
ACH-001523	skin_squamous	MRPS30	10884	2.680006	-0.302865	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	LTK	4058	2.039894	-0.148356	NaN	True	True
ACH-000859	breast_HER2Amp	PGAP3	93210	54.124990	-0.366416	-0.085402	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	SULF1	23213	3.006152	-0.193665	NaN	True	True
ACH-000280	ovary_non_epithelial	CYP2J2	1573	3.466104	-0.277471	-0.011558	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	C2CD3	26005	2.616111	-0.036814	NaN	True	True
ACH-001524	skin_squamous	ZNF622	90441	2.007874	-0.283130	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CCDC89	220388	2.677035	-0.033870	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FBN1	2200	2.028902	-0.082453	NaN	True	True
ACH-000859	breast_HER2Amp	MIEN1	84299	54.124990	-0.590896	0.066007	True	True
ACH-001524	skin_squamous	CEP72	55722	2.061718	-0.159356	NaN	False	True
ACH-001554	eye_uveal_melanoma	TCIM	56892	2.267856	-0.255243	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SRRD	402055	2.035225	-0.436161	NaN	False	True
ACH-001554	eye_uveal_melanoma	SULF1	23213	2.267856	-0.072933	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GRK2	156	2.566798	-0.339662	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	TTBK1	84630	2.060374	-0.529445	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FAM76B	143684	2.622517	-0.131378	NaN	False	True
ACH-001554	eye_uveal_melanoma	FGFR1	2260	2.267856	-0.079191	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	THAP12	5612	2.677035	-0.565188	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	IL17A	3605	2.060374	-0.114599	NaN	False	False
ACH-001554	eye_uveal_melanoma	PLEKHF2	79666	2.701722	-0.024850	NaN	False	True
ACH-001523	skin_squamous	DROSHA	29102	3.020449	-0.320750	NaN	True	True
ACH-001554	eye_uveal_melanoma	ADCY8	114	2.701722	-0.119059	NaN	True	False
ACH-000025	central_nervous_system_meningioma	SIRPA	140885	14.136960	-0.091368	-0.075511	True	True
ACH-001554	eye_uveal_melanoma	FBXL6	26233	2.701722	-0.153436	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TBC1D22A	25771	3.510431	-0.157334	NaN	True	True
ACH-001554	eye_uveal_melanoma	DKK4	27121	2.267856	-0.128231	NaN	True	False
ACH-001554	eye_uveal_melanoma	RIDA	10247	2.701722	-0.005946	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TNFAIP8L3	388121	2.028902	-0.071961	NaN	False	True
ACH-001524	skin_squamous	ZDHHC11	79844	5.882604	-0.465027	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	HYPK	25764	2.028902	-0.979438	NaN	False	True
ACH-000280	ovary_non_epithelial	AP4S1	11154	2.050516	-0.187472	0.178102	False	True
ACH-001554	eye_uveal_melanoma	TSNARE1	203062	2.701722	-0.160162	NaN	False	True
ACH-001524	skin_squamous	CCT5	22948	2.007874	-0.818343	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	RPP21	79897	2.145172	-1.575234	NaN	False	True
ACH-000017	breast_HER2Amp	NEUROD2	4761	10.553327	-0.349924	0.049887	False	True
ACH-001554	eye_uveal_melanoma	NSMAF	8439	2.267856	-0.056673	NaN	True	True
ACH-000280	ovary_non_epithelial	PVR	5817	2.085358	-0.104171	-0.011868	True	True
ACH-001521	skin_squamous	SLC6A19	340024	2.355673	-0.007743	NaN	True	False
ACH-001524	skin_squamous	UGT3A2	167127	2.007874	-0.067524	NaN	True	True
ACH-001554	eye_uveal_melanoma	NKX6-3	157848	2.267856	-0.041824	NaN	False	False
ACH-001554	eye_uveal_melanoma	POU5F1B	5462	2.701722	-0.639591	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	C6orf132	647024	2.060374	-0.205863	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	ANKRD66	100287718	2.060374	-0.102714	NaN	False	False
ACH-001523	skin_squamous	TARS	6897	3.020449	-1.153123	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	RHAG	6005	2.060374	-0.000017	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	KREMEN1	83999	2.612317	-0.419952	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	CRIP3	401262	2.060374	-0.308739	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	KLC4	89953	2.060374	-0.281315	NaN	False	True
ACH-001523	skin_squamous	RICTOR	253260	2.680006	-0.395870	NaN	True	True
ACH-000248	breast_HER2Amp	IKZF3	22806	9.627685	-0.550712	-0.084285	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ZNF383	163087	3.544409	-0.084208	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SLC28A2	9153	2.028902	-0.007776	NaN	True	True
ACH-001554	eye_uveal_melanoma	TONSL	4796	2.701722	-1.232954	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MMP20	9313	2.482392	-0.298998	NaN	False	False
ACH-001957	bone_chordoma	AUTS2	26053	2.193289	-0.183862	NaN	False	False
ACH-001554	eye_uveal_melanoma	CA1	759	2.267856	-0.014887	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PPP1R14D	54866	2.039894	-0.167110	NaN	False	False
ACH-001554	eye_uveal_melanoma	TUSC3	7991	2.267856	-0.165660	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MRPS10	55173	2.060374	-0.668123	NaN	False	True
ACH-001524	skin_squamous	OTULIN	90268	2.007874	-0.205117	NaN	False	True
ACH-001554	eye_uveal_melanoma	CDCA2	157313	2.267856	-0.127998	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MRPS18A	55168	2.060374	-0.578454	NaN	False	True
ACH-001554	eye_uveal_melanoma	CRH	1392	2.267856	-0.190811	NaN	False	False
ACH-001554	eye_uveal_melanoma	ZNF696	79943	2.701722	-0.411693	NaN	False	True
ACH-001554	eye_uveal_melanoma	CHRNA2	1135	2.267856	-0.049738	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	ADORA2A	135	2.543976	-0.392971	NaN	False	True
ACH-001523	skin_squamous	C5orf38	153571	3.020449	-0.181106	NaN	True	True
ACH-001554	eye_uveal_melanoma	MTDH	92140	2.701722	-0.060657	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TFIP11	24144	2.035225	-0.377372	NaN	False	True
ACH-001524	skin_squamous	ZNF131	7690	2.007874	-0.843185	NaN	True	True
ACH-001554	eye_uveal_melanoma	CHRNA6	8973	2.267856	-0.031563	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	FNDC7	163479	2.492409	-0.264649	NaN	True	False
ACH-001554	eye_uveal_melanoma	LAPTM4B	55353	2.701722	-0.017135	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	AMFR	267	3.427301	-0.524274	NaN	False	True
ACH-001554	eye_uveal_melanoma	ZFP41	286128	2.701722	-0.041662	NaN	False	True
ACH-001554	eye_uveal_melanoma	KLHL38	340359	2.701722	-0.145699	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	PGC	5225	2.060374	-0.110362	NaN	False	False
ACH-001328	skin_epidermoid_carcinoma	PSPH	5723	4.556424	-0.227270	NaN	False	True
ACH-001523	skin_squamous	ICE1	23379	3.020449	-0.358013	NaN	False	True
ACH-001554	eye_uveal_melanoma	RDH10	157506	2.267856	-0.172447	NaN	True	True
ACH-001524	skin_squamous	MRPS30	10884	2.007874	-0.103342	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	UCP3	7352	2.616111	-0.027199	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CPT1A	1374	2.454952	-0.441671	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ALG8	79053	2.677035	-0.452036	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CREBZF	58487	2.677035	-0.405693	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	LRRC1	55227	2.060374	-0.517280	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MED20	9477	2.060374	-0.312157	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	VWA2	340706	3.457480	-0.034333	NaN	False	True
ACH-000280	ovary_non_epithelial	OMA1	115209	3.466104	-0.298016	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	CRISP2	7180	2.060374	-0.011186	NaN	True	False
ACH-001554	eye_uveal_melanoma	FAM135B	51059	2.701722	-0.277736	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	HDC	3067	2.028902	-0.181419	NaN	True	True
ACH-001521	skin_squamous	CCDC127	133957	2.869776	-0.037123	NaN	True	True
ACH-001521	skin_squamous	TRIP13	9319	2.869776	-0.325047	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	CIC	23152	3.447860	-0.819055	NaN	True	True
ACH-001554	eye_uveal_melanoma	UTP23	84294	2.701722	-0.643498	NaN	True	True
ACH-001521	skin_squamous	SLC6A3	6531	2.355673	-0.058445	NaN	True	False
ACH-001521	skin_squamous	C5orf49	134121	2.355673	-0.235500	NaN	True	False
ACH-001328	skin_epidermoid_carcinoma	TBCC	6903	2.060374	-0.955797	NaN	False	True
ACH-001554	eye_uveal_melanoma	PPP1R16A	84988	2.701722	-0.152665	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ATG16L2	89849	2.616111	-0.213095	NaN	False	True
ACH-000280	ovary_non_epithelial	POTEM	641455	2.776707	-0.324368	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	LRP5L	91355	3.253533	-0.311703	NaN	False	True
ACH-001521	skin_squamous	ZFR	51663	2.138119	-0.123865	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	CTSO	1519	2.527594	-0.267859	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	LRRC73	221424	2.060374	-0.441080	NaN	False	True
ACH-001554	eye_uveal_melanoma	UBR5	51366	2.701722	-0.763335	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MIF	4282	2.543976	-0.313925	NaN	False	True
ACH-001554	eye_uveal_melanoma	INTS9	55756	2.267856	-1.433624	NaN	True	True
ACH-001521	skin_squamous	SRD5A1	6715	2.355673	-0.228733	NaN	False	True
ACH-001554	eye_uveal_melanoma	FAM91A1	157769	2.701722	-0.125802	NaN	True	True
ACH-001554	eye_uveal_melanoma	MAK16	84549	2.267856	-1.616192	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	FAM227B	196951	2.028902	-0.154859	NaN	True	True
ACH-001554	eye_uveal_melanoma	VIRMA	25962	2.701722	-0.816171	NaN	True	True
ACH-001554	eye_uveal_melanoma	MSC	9242	2.267856	-0.051447	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CARNS1	57571	2.566798	-0.244150	NaN	False	True
ACH-001554	eye_uveal_melanoma	RNF139	11236	2.701722	-0.233586	NaN	True	True
ACH-000711	breast_HER2Amp	MIEN1	84299	7.195136	-0.387982	0.075505	True	True
ACH-001554	eye_uveal_melanoma	HGH1	51236	2.701722	-0.116980	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	INTS6	26512	3.701236	-0.665060	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	PHKG1	5260	4.556424	-0.466095	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RHOV	171177	2.039894	-0.075012	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	IGHMBP2	3508	2.454952	-0.376013	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MGA	23269	2.039894	-0.435681	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	LEO1	123169	2.028902	-0.236190	NaN	False	True
ACH-001554	eye_uveal_melanoma	COX6C	1345	2.701722	-0.543872	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	FLOT1	10211	2.145172	-0.340217	NaN	False	True
ACH-001523	skin_squamous	ROPN1L	83853	3.020449	-0.390478	NaN	False	True
ACH-001554	eye_uveal_melanoma	EIF4EBP1	1978	2.267856	-0.345970	NaN	False	True
ACH-000280	ovary_non_epithelial	TACSTD2	4070	3.466104	-0.441444	0.069882	False	True
ACH-001554	eye_uveal_melanoma	PI15	51050	2.267856	-0.056003	NaN	True	True
ACH-001554	eye_uveal_melanoma	SLC25A32	81034	2.701722	-0.152602	NaN	True	True
ACH-001554	eye_uveal_melanoma	TMEM64	169200	2.267856	-0.405920	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ENDOD1	23052	2.622517	-0.100468	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CHAC1	79094	2.039894	-0.181518	NaN	False	True
ACH-001554	eye_uveal_melanoma	GPAT4	137964	2.267856	-0.003480	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CEP57	9702	2.622517	-0.086717	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	OR52I2	143502	3.093847	-0.184534	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	SMARCB1	6598	2.543976	-1.008529	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RGL4	266747	2.543976	-0.158712	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	GSTA1	2938	2.060374	-0.261615	NaN	False	False
ACH-001524	skin_squamous	TENT4A	11044	2.007874	-0.130822	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	UCP2	7351	2.616111	-0.067186	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CEP152	22995	2.028902	-0.343506	NaN	True	True
ACH-001554	eye_uveal_melanoma	FAM86B2	653333	2.267856	-0.016279	NaN	False	True
ACH-001524	skin_squamous	RICTOR	253260	2.007874	-0.229251	NaN	True	True
ACH-000025	central_nervous_system_meningioma	ALAS2	212	3.549461	NaN	0.170521	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RAD9A	5883	2.566798	-1.194931	NaN	False	True
ACH-001524	skin_squamous	DAP	1611	2.007874	-0.118214	NaN	False	True
ACH-001521	skin_squamous	SLC12A7	10723	2.869776	-0.229027	NaN	False	True
ACH-001554	eye_uveal_melanoma	ODF1	4956	2.701722	-0.059808	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	SLCO2B1	11309	2.677035	-0.010783	NaN	False	True
ACH-001524	skin_squamous	WDR70	55100	2.007874	-0.528528	NaN	False	True
ACH-001554	eye_uveal_melanoma	RHOBTB2	23221	2.267856	-0.080490	NaN	False	True
ACH-001554	eye_uveal_melanoma	THAP1	55145	2.267856	-1.393016	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SLC12A1	6557	2.028902	-0.053865	NaN	True	False
ACH-000017	breast_HER2Amp	PGAP3	93210	10.553327	-0.169483	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TPST2	8459	2.612317	-0.030371	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	TFAP2D	83741	2.060374	-0.146016	NaN	True	False
ACH-001523	skin_squamous	ZFR	51663	3.020449	-0.142241	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	DUOX2	50506	2.028902	-0.264055	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	VSTM5	387804	2.622517	-0.369100	NaN	False	True
ACH-001554	eye_uveal_melanoma	RAB2A	5862	2.267856	-0.119570	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	JRKL	8690	2.996424	-0.048604	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	OIP5	11339	2.039894	-1.205676	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	NFKBIE	4794	2.060374	-0.751921	NaN	False	True
ACH-001523	skin_squamous	HMGCS1	3157	2.680006	-0.802344	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	DNPH1	10591	2.060374	-0.198612	NaN	False	True
ACH-001554	eye_uveal_melanoma	ESCO2	157570	2.267856	-0.211492	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PLEKHB1	58473	2.616111	-0.319015	NaN	True	True
ACH-001554	eye_uveal_melanoma	TERF1	7013	2.267856	-0.999663	NaN	False	True
ACH-001554	eye_uveal_melanoma	LYPLA1	10434	2.267856	-0.240780	NaN	True	True
ACH-001521	skin_squamous	ANKRD33B	651746	2.355673	-0.099667	NaN	False	True
ACH-001554	eye_uveal_melanoma	HEY1	23462	2.267856	-0.023385	NaN	False	True
ACH-001524	skin_squamous	AGXT2	64902	2.007874	-0.076184	NaN	True	False
ACH-001554	eye_uveal_melanoma	ELOC	6921	2.267856	-0.560869	NaN	False	True
ACH-000280	ovary_non_epithelial	NECTIN2	5819	2.085358	-0.205915	-0.070616	False	True
ACH-001554	eye_uveal_melanoma	TNKS	8658	2.267856	-0.183412	NaN	True	True
ACH-000280	ovary_non_epithelial	DOCK7	85440	3.466104	-0.385960	NaN	True	True
ACH-000280	ovary_non_epithelial	PATJ	10207	3.466104	-0.187960	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	STRC	161497	2.028902	-0.261810	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	CDC5L	988	2.060374	-1.512587	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CLPB	81570	2.775982	-0.246576	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GSTP1	2950	2.566798	-0.332132	NaN	False	True
ACH-001554	eye_uveal_melanoma	RP1L1	94137	2.267856	-0.273962	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NAALAD2	10003	2.991123	-0.066767	NaN	True	True
ACH-001554	eye_uveal_melanoma	INTS8	55656	2.701722	-0.655642	NaN	True	True
ACH-001554	eye_uveal_melanoma	PUF60	22827	2.701722	-1.557077	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	WDR76	79968	2.028902	-0.429551	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PITPNM1	9600	2.566798	-0.370629	NaN	True	True
ACH-001554	eye_uveal_melanoma	EXT1	2131	2.701722	-0.069589	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	HSCB	150274	2.612317	-0.635648	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CCND1	595	2.454952	-1.490283	NaN	True	True
ACH-001554	eye_uveal_melanoma	TMEM70	54968	2.267856	-0.039141	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	TACC2	10579	3.390253	-0.074676	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	NADSYN1	55191	2.775982	-0.060850	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	CUL7	9820	2.060374	-0.670017	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	GPR152	390212	2.566798	-0.177833	NaN	False	False
ACH-001554	eye_uveal_melanoma	UQCRB	7381	2.701722	-0.709810	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	CYP3A43	64816	2.796201	-0.251472	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	VPS39	23339	2.039894	-0.502327	NaN	True	True
ACH-001554	eye_uveal_melanoma	NPBWR1	2831	2.267856	-0.140563	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	FUT4	2526	2.622517	-0.419206	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	LAMTOR1	55004	2.775982	-0.305999	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	MMP3	4314	2.482392	-0.052730	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	UTF1	8433	3.227021	-0.001818	NaN	False	False
ACH-001523	skin_squamous	PAIP1	10605	2.680006	-0.024182	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ARRB1	408	2.677035	-0.192355	NaN	False	True
ACH-001554	eye_uveal_melanoma	MAF1	84232	2.701722	-0.284791	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	AP4E1	23431	2.028902	-0.072631	NaN	True	True
ACH-001521	skin_squamous	TERT	7015	2.355673	-0.586357	NaN	False	False
ACH-001346	upper_aerodigestive_buccal_mucosa	RPAP1	26015	2.039894	-1.348167	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	SGSM1	129049	3.253533	-0.305549	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	GNMT	27232	2.060374	-0.235170	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	GTPBP2	54676	2.060374	-0.302628	NaN	False	True
ACH-001523	skin_squamous	EXOC3	11336	3.020449	-0.498233	NaN	False	True
ACH-001328	skin_epidermoid_carcinoma	MAD2L1BP	9587	2.060374	-0.602011	NaN	False	True
ACH-001554	eye_uveal_melanoma	KCNQ3	3786	2.701722	-0.038287	NaN	True	False
ACH-001328	skin_epidermoid_carcinoma	CNPY3	10695	2.060374	-0.097984	NaN	True	True
ACH-001521	skin_squamous	SDHA	6389	2.869776	-0.534472	NaN	False	True
ACH-001554	eye_uveal_melanoma	PDGFRL	5157	2.267856	-0.007048	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	POLD4	57804	2.566798	-0.263875	NaN	False	True
ACH-000280	ovary_non_epithelial	FOXD3	27022	3.466104	-0.347443	0.184320	False	True
ACH-001524	skin_squamous	HMGCS1	3157	2.007874	-0.908590	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	ANGPTL5	253935	6.241215	-0.074588	NaN	False	True
ACH-000025	central_nervous_system_meningioma	CDS2	8760	14.136960	-0.145001	0.124849	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PANK3	79646	3.759011	-0.070301	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PIWIL4	143689	2.622517	-0.163549	NaN	True	True
ACH-001554	eye_uveal_melanoma	RPS20	6224	2.267856	-1.931117	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	RNF121	55298	2.775982	-0.207823	NaN	False	True
ACH-001521	skin_squamous	ANKH	56172	2.138119	-0.205069	NaN	True	True
ACH-000711	breast_HER2Amp	GRB7	2886	7.195136	-0.134284	-0.130875	False	True
ACH-001521	skin_squamous	TARS	6897	2.138119	-1.616285	NaN	False	True
ACH-001554	eye_uveal_melanoma	GINS4	84296	2.267856	-0.964356	NaN	False	True
ACH-000025	central_nervous_system_meningioma	PHF8	23133	5.051108	NaN	NaN	False	True
ACH-001524	skin_squamous	LRRC14B	389257	2.061718	-0.241116	NaN	False	False
ACH-001521	skin_squamous	MARCH6	10299	2.355673	-0.587605	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TYRO3	7301	2.039894	-0.139795	NaN	True	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	ATP13A4	84239	2.989570	-0.174887	NaN	False	True
ACH-001524	skin_squamous	NIPBL	25836	2.007874	-0.258418	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CORO1B	57175	2.566798	-0.061536	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	PCF11	51585	2.677035	-0.622813	NaN	True	True
ACH-001554	eye_uveal_melanoma	RHBDF2	79651	2.027413	-0.207760	NaN	True	True
ACH-001554	eye_uveal_melanoma	NIPAL2	79815	2.701722	-0.181085	NaN	True	True
ACH-001554	eye_uveal_melanoma	POLR3D	661	2.267856	-0.570728	NaN	True	True
ACH-001328	skin_epidermoid_carcinoma	MLIP	90523	2.060374	-0.061400	NaN	True	True
ACH-001554	eye_uveal_melanoma	ARFGEF1	10565	2.267856	-0.070906	NaN	True	True
ACH-001346	upper_aerodigestive_buccal_mucosa	TBX10	347853	2.475256	-0.365703	NaN	True	False
ACH-001346	upper_aerodigestive_buccal_mucosa	ANKRD42	338699	2.677035	-0.277655	NaN	True	True
ACH-001554	eye_uveal_melanoma	MCMDC2	157777	2.267856	-0.082284	NaN	True	True
ACH-000859	breast_HER2Amp	STARD3	10948	54.124990	-0.404351	-0.010224	False	True
ACH-001328	skin_epidermoid_carcinoma	GLYATL3	389396	2.060374	-0.249913	NaN	False	False
ACH-001164	soft_tissue_sarcoma_undifferentiated	PDLIM1	9124	2.452457	-0.153164	NaN	False	True
ACH-001346	upper_aerodigestive_buccal_mucosa	CEP295	85459	2.622517	-0.376415	NaN	True	True
ACH-001524	skin_squamous	MTMR12	54545	2.007874	-0.032385	NaN	False	True
ACH-001164	soft_tissue_sarcoma_undifferentiated	PSG6	5675	2.072998	-0.688199	NaN	False	False
ACH-001521	skin_squamous	FBXL7	23194	2.138119	-0.028310	NaN	True	False